Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns

Glia
Joshua G Jackson, Michael B Robinson

Abstract

Astrocytes are the major glial cell in the central nervous system. These polarized cells possess numerous processes that ensheath the vasculature and contact synapses. Astrocytes play important roles in synaptic signaling, neurotransmitter synthesis and recycling, control of nutrient uptake, and control of local blood flow. Many of these processes depend on local metabolism and/or energy utilization. While astrocytes respond to increases in neuronal activity and metabolic demand by upregulating glycolysis and glycogenolysis, astrocytes also possess significant capacity for oxidative (mitochondrial) metabolism. Mitochondria mediate energy supply and metabolism, cellular survival, ionic homeostasis, and proliferation. These organelles are dynamic structures undergoing extensive fission and fusion, directed movement along cytoskeletal tracts, and degradation. While many of the mechanisms underlying the dynamics of these organelles and their physiologic roles have been characterized in neurons and other cells, the roles that mitochondrial dynamics play in glial physiology is less well understood. Recent work from several laboratories has demonstrated that mitochondria are present within the fine processes of astrocytes, that their ...Continue Reading

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Feb 2, 1979·Brain Research·M D Norenberg, A Martinez-Hernandez
Jan 1, 1979·Journal of Supramolecular Structure·T J Bradley, P Satir
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P W BaasG A Banker
Jul 8, 1986·The Journal of Comparative Neurology·T Kosaka, K Hama
Jun 1, 1971·Journal of Molecular and Cellular Cardiology·B SaferJ R Williamson
Jun 1, 1972·The Biochemical Journal·R M DentonB R Martin
Oct 1, 1982·Journal of Neurochemistry·A C YuL Hertz
Nov 1, 1983·Journal of Neurochemistry·A C YuA Schousboe
Jun 30, 1994·Nature·V ParpuraP G Haydon
Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Jun 1, 1994·Glia·Y Shao, K D McCarthy
Sep 1, 1994·The Journal of Cell Biology·R RizzutoT Pozzan
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K Janeczko
Dec 1, 1995·The Journal of Cell Biology·R L Morris, P J Hollenbeck
Jan 1, 1996·Journal of Neurochemistry·M C McKennaH R Zielke
Oct 17, 1996·Nature·N Zerangue, M P Kavanaugh
Nov 1, 1996·The Journal of Cell Biology·A F Davis, D A Clayton
Apr 1, 1996·Journal of Bioenergetics and Biomembranes·P Bernardi, V Petronilli
Jun 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S KirischukA Verkhratsky
May 14, 1999·Trends in Neurosciences·A AraqueP G Haydon
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·L S JouavilleR Rizzuto
Feb 9, 2000·American Journal of Physiology. Cell Physiology·P R TerritoR S Balaban
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·M A MartinW M Saxton

❮ Previous
Next ❯

Citations

Feb 21, 2018·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Peter A LarsenAnn M Saunders
Feb 9, 2019·The Journal of Physiology·Alexei VerkhratskyChristine R Rose
Mar 17, 2020·Current Protocols in Neuroscience·Julia K FarnanJoshua G Jackson
Jun 26, 2020·Journal of Receptor and Signal Transduction Research·David Mui, Ying Zhang
Aug 18, 2020·Human Molecular Genetics·Alexey V ShevelkinMikhail V Pletnikov
May 18, 2020·Glia·Ingrid MoralesManuel Rodriguez
Nov 23, 2018·Epilepsy Currents·Manisha Patel
Aug 21, 2018·Frontiers in Cellular Neuroscience·Diana MatiasVivaldo Moura-Neto
Dec 20, 2018·Physiological Reviews·Gerald A Dienel
Sep 10, 2020·Frontiers in Physiology·Lisa FelixChristine R Rose
Dec 15, 2020·Biological Reviews of the Cambridge Philosophical Society·Zhe ShiXin-Min Liu
Jan 17, 2021·International Journal of Molecular Sciences·Enrique MadrugaAna Martínez
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Matteo Bergami, Elisa Motori
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Collin M BantleEvgeny Shlevkov
Jan 27, 2020·Progress in Retinal and Eye Research·Eun Jung LeeChangwon Kee
Jul 3, 2021·Metabolites·Niklas Meyer, Johanne Egge Rinholm
Jun 22, 2021·Journal of Neuroimmunology·Rishabh ChaudharyEmma Steinson
Aug 13, 2021·Frontiers in Cellular Neuroscience·Aaron J MoulsonPeggy Assinck
Jul 16, 2020·Journal of Ethnopharmacology·Jun WangLin Li
Sep 14, 2021·Cellular and Molecular Neurobiology·Kumari PreetiValencia Fernandes
Oct 21, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yijun MoChanghui Yu
Jan 22, 2022·ACS Chemical Neuroscience·Hongji Wang, Changshui Xu
Jan 28, 2022·Journal of Neuroscience Research·Gonzalo Mayorga-WeberMaite A Castro
Jan 29, 2022·FEBS Letters·Diogo TrigoOdete da Cruz E Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

© 2022 Meta ULC. All rights reserved