Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells

The Journal of Biological Chemistry
Sukhamoy DhabalAshish Bhattacharjee

Abstract

Monoamine oxidase A (MAO-A) is a mitochondrial flavoenzyme implicated in the pathogenesis of atherosclerosis and inflammation and also in many neurological disorders. MAO-A also has been reported as a potential therapeutic target in prostate cancer. However, the regulatory mechanisms controlling cytokine-induced MAO-A expression in immune or cancer cells remain to be identified. Here, we show that MAO-A expression is co-induced with 15-lipoxygenase (15-LO) in interleukin 13 (IL-13)-activated primary human monocytes and A549 non-small cell lung carcinoma cells. We present evidence that MAO-A gene expression and activity are regulated by signal transducer and activator of transcription 1, 3, and 6 (STAT1, STAT3, and STAT6), early growth response 1 (EGR1), and cAMP-responsive element-binding protein (CREB), the same transcription factors that control IL-13-dependent 15-LO expression. We further established that in both primary monocytes and in A549 cells, IL-13-stimulated MAO-A expression, activity, and function are directly governed by 15-LO. In contrast, IL-13-driven expression and activity of MAO-A was 15-LO-independent in U937 promonocytic cells. Furthermore, we demonstrate that the 15-LO-dependent transcriptional regulation o...Continue Reading

References

Oct 30, 1992·Biochimica Et Biophysica Acta·S Yamamoto
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J ConradE Sigal
Jan 1, 1980·Journal of Immunological Methods·W FalkE J Leonard
Jul 1, 1995·The Journal of Clinical Investigation·V A FolcikM K Cathcart
May 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T P Singer, R R Ramsay
Nov 1, 1993·Metabolism: Clinical and Experimental·G PanagiotidisI Lundquist
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerJ M Lehmann
Aug 18, 2000·Free Radical Biology & Medicine·M K Cathcart, V A Folcik
Jul 28, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C D BrownS Jenkinson
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K A Carnevale, M K Cathcart
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Feb 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fanny RobbesynAnne Negre-Salvayre
Oct 1, 2003·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·Joanna S. FowlerJean Logan
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pavlos ChaitidisHartmut Kühn
Oct 20, 2004·The Journal of Biological Chemistry·Karsten GroteBernhard Schieffer
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Nov 27, 2004·Natural Product Reports·Nigel S Scrutton
May 9, 2006·Progress in Lipid Research·Hartmut Kühn, Valerie B O'Donnell
Jul 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Ming OuJean C Shih
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashish BhattacharjeeMartha K Cathcart
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fernando O MartinezAlberto Mantovani
Nov 7, 2006·Analytical Biochemistry·Michael P ValleyKeith V Wood
Jun 15, 2007·Free Radical Biology & Medicine·Christelle CoatrieuxNathalie Auge
Sep 18, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jonas Wittwer, Martin Hersberger
Jan 23, 2008·The Journal of Experimental Medicine·Ravi S MishraMartha K Cathcart
Apr 26, 2008·Nature Reviews. Immunology·Charles N SerhanThomas E Van Dyke
Nov 5, 2008·Genes & Development·Martina I LefterovaMitchell A Lazar
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Jan 28, 2009·Nature Structural & Molecular Biology·Toshimasa ItohJohn W R Schwabe
Feb 17, 2009·American Journal of Respiratory and Critical Care Medicine·Jinming ZhaoSally E Wenzel
Jun 1, 2010·Immunity·Siamon Gordon, Fernando O Martinez
Sep 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashish BhattacharjeeMartha K Cathcart
Sep 28, 2010·Biochimica Et Biophysica Acta·Nina KaludercicNazareno Paolocci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.