PMID: 11607188Jun 1, 1991Paper

Regulation of movement speed by intracellular pH during Dictyostelium discoideum chemotaxis

Proceedings of the National Academy of Sciences of the United States of America
B Van Duijn, K Inouye

Abstract

Evidence is presented that the chemoattractant-induced cytoplasmic alkalinization in the cellular slime mold Dictyostelium discoideum is essential in regulating locomotion speed during chemotaxis. Intracellular pH was manipulated with weak bases, weak acids, and proton-pump inhibition. Speed of locomotion of individual cells was measured during random and chemotactic movement. We found that (i) an increase of cytoplasmic pH increases the speed of randomly moving cells and (ii) the chemoattractant-induced rise in intracellular pH is essential for the increase in directed locomotion speed upon chemotactic stimulation. In addition, our experiments support the hypothesis that ammonia plays a key role in the thermo- and phototaxis of migrating slugs by increasing the locomotion speed of individual cells through changes in intracellular pH.

References

Sep 1, 1978·Experimental Cell Research·A J Durston, F Vork
Jan 1, 1988·Annual Review of Cell Biology·P N Devreotes, S H Zigmond
Aug 17, 1987·FEBS Letters·R J AertsM M Van Lookeren Campagne
Mar 1, 1985·Pflügers Archiv : European journal of physiology·C InceM M Diesselhoff
Apr 1, 1971·Journal of Theoretical Biology·M H Cohen, A Robertson
Sep 1, 1980·The Journal of Cell Biology·J M Heiple, D L Taylor
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J T BonnerH B Suthers
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J T BonnerH B Suthers

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Citations

Mar 1, 1992·Cancer Metastasis Reviews·J CondeelisJ E Segall
Oct 2, 2003·European Journal of Biochemistry·Emeline LagarrigueClaude Roustan
May 20, 2003·Evolution & Development·John Tyler Bonner
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Siegert, C J Weijer
Mar 3, 2005·Development, Growth & Differentiation·John Sternfeld, Ryan O'Mara
Sep 29, 2011·Development, Growth & Differentiation·Kerry A FlegelCynthia K Damer
Nov 26, 2008·The Journal of Cell Biology·Christian FrantzDiane L Barber
Apr 25, 2000·The Journal of General Physiology·M KleinA Schwab
Aug 6, 1999·Journal of Theoretical Biology· Mar e AFP Hogeweg
Jun 13, 2003·Molecular Biology of the Cell·Violaine DelormeIsabelle Tardieux
Feb 10, 2007·Physiology·Jyoti SrivastavaMatthew P Jacobson
Mar 15, 1996·The Journal of Biological Chemistry·R HooleyD L Barber
Nov 14, 2013·Anesthesiology and Pain Medicine·Menno E Sluijter, Farnad Imani
Jun 23, 1995·The Journal of Biological Chemistry·B T EdmondsJ Condeelis
Sep 1, 1994·Microbiological Reviews·J D Gross
Mar 11, 2000·Plant Physiology·W D Ransom-HodgkinsW F Boss

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