PMID: 2509381Jan 1, 1989Paper

Regulation of murine hematopoiesis by arachidonic acid metabolites

International Journal of Immunopharmacology
S J VoreM I Luster

Abstract

Arachidonic acid metabolites have been shown to exert a variety of regulatory effects on cellular activation and proliferation. Recently, a role for these products as regulators of hematopoiesis was suggested and evidence provided that products of the lipoxygenase pathway, specifically leukotrienes, are essential for human myeloid colony formation in vitro. In this report the broader role of these metabolites in hematopoiesis was examined using murine bone marrow stem cell assays for both myeloid and lymphoid cell lines. The effects of lipoxygenase and/or cyclooxygenase pathway inhibitors on stem cell colony formation were evaluated and compared to qualitative and quantitative changes in arachidonic acid metabolism that occurred in similarly treated bone marrow cell cultures. Interruption of the lipoxygenase pathway by esculetin or nordihydroguaiaretic acid resulted in decreased colony formation in both lymphoid and myeloid stem cells. This inhibition of colony growth was partly reversed by the addition of leukotrienes and was particularly evident in B-cell progenitor cultures to which was added LTB4. Inhibition of the cyclooxygenase pathway by indomethacin or ibuprofen had a slight stimulatory effect on myeloid colony formatio...Continue Reading

References

Apr 1, 1979·The Journal of Clinical Investigation·S Rittenhouse-Simmons
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Citations

Dec 1, 1989·Current Opinion in Immunology·J S Goodwin
Jul 1, 1996·Critical Reviews in Oncology/hematology·C Denzlinger
Feb 5, 1999·Leukemia Research·K M AndersonJ E Harris
Aug 19, 2003·Reproduction, Fertility, and Development·Jianbo HuMark A Mirando
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Maria Teresa Rizzo
Sep 8, 2007·Journal of Applied Physiology·A S BrownE P Mayer
Mar 6, 2002·British Journal of Pharmacology·Letícia LintomenP Xavier Elsas
Oct 2, 2003·The Journal of Nutrition·Josep Bassaganya-RieraRaquel Hontecillas
Jul 30, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H Harizi, N Gualde

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