Regulation of muscle acetylcholine receptor-channel function by interferon.

Pflügers Archiv : European journal of physiology
Fabrizio EusebiA Santoni

Abstract

The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-beta) in the mouse myotubes, and with IFN-beta and leucocytes IFN (IFN-alpha), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

References

Nov 7, 1977·Biochemical and Biophysical Research Communications·M F MeldolesiL D Kohn
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M G ToveyM Castagna
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P MiddletonS M Schuetze
Oct 15, 1986·Biochemical and Biophysical Research Communications·B M ZaniF Eusebi
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P Brehm, R Kullberg
Sep 30, 1987·Biochemical and Biophysical Research Communications·F GrassiF Eusebi
Feb 1, 1988·The Journal of Physiology·F Jaramillo, S M Schuetze
Aug 23, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F EusebiF Ruzzier
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K MilesR L Huganir
Apr 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F EusebiM Molinaro
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W H YapY H Tan
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J SchneckB R Bloom
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Sep 21, 1984·Science·E J NestlerP Greengard

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Citations

Oct 1, 1991·Pflügers Archiv : European journal of physiology·P LorenzonF Eusebi

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