Regulation of myocardial fibrosis by MicroRNAs

Journal of Cardiovascular Pharmacology
Johann Bauersachs

Abstract

Interstitial and perivascular fibrosis is a hallmark of adverse cardiac remodeling in response to stress such as hypertension, valve disease, or myocardial infarction. The cross talk between fibroblasts and cardiomyocytes seems to be a major determinant of the hypertrophic response, and fibroblasts may prove to be essential regulators of cardiac remodeling. The present review summarizes current knowledge on the modulation of myocardial fibrosis by microRNAs (miRNAs), single-stranded molecules consisting of approximately 22 noncoding nucleotides that regulate a variety of target genes involved in cardiovascular (patho)physiology. Dissection of miRNA-mediated mechanisms on myocardial and cellular and subcellular levels will provide insights into the impact of miRNAs for cardiac structural changes induced by different stressors and also expand our understanding of the interdependence of different cell types in the heart with regard to extracellular matrix formation during healing and remodeling after myocardial infarction or in response to pressure overload. The first successful treatment of fibrosis and failure in a murine pressure overload model by application of miRNA antagonists such as antagomirs in vivo raises the hope that ...Continue Reading

References

Oct 7, 2003·Nature Genetics·Emily BernsteinGregory J Hannon
Sep 17, 2004·Nature·Victor Ambros
Jan 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Mizuho MiyauchiHrayr S Karagueuzian
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Jan 31, 2006·Lancet·Lionel H OpieMarc A Pfeffer
Nov 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Jan 20, 2007·Circulation Research·Danish SayedMaha Abdellatif
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mitsuo KatoRama Natarajan
May 1, 2007·Nature Medicine·Alessandra CarèGianluigi Condorelli
May 2, 2007·Circulation·Ralph B D'Agostino
May 15, 2007·Journal of Molecular and Cellular Cardiology·Mariko TatsuguchiDa-Zhi Wang
May 26, 2007·The American Journal of Pathology·Yunhui ChengChunxiang Zhang
Jul 4, 2007·Circulation·Thomas ThumJohann Bauersachs
Jul 31, 2007·Nature Medicine·Elisabeth M ZeisbergRaghu Kalluri
Aug 23, 2007·Physiological Genomics·Sadakatsu IkedaWilliam T Pu
Nov 2, 2007·European Journal of Clinical Investigation·J Bauersachs, T Thum
Feb 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jian-Fu ChenDa-Zhi Wang
Feb 8, 2008·The EMBO Journal·Ann-Bin ShyuAmbro van Hoof
Mar 28, 2008·The New England Journal of Medicine·Joseph A Hill, Eric N Olson
May 30, 2008·Molecular Biology of the Cell·Danish SayedMaha Abdellatif
May 31, 2008·Cardiovascular Research·Thomas ThumJohann Bauersachs
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiang WangRichard J Quigg
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Sep 24, 2008·Circulation·Paula A da Costa MartinsLeon J De Windt
Nov 4, 2008·Cardiovascular Research·Stefan FrantzGeorg Ertl
Jan 31, 2009·Circulation Research·Eva van Rooij, Eric N Olson
Apr 2, 2009·Journal of Molecular and Cellular Cardiology·Yunhui ChengChunxiang Zhang
Apr 4, 2009·The Journal of Biological Chemistry·Zhaoyong LiJane B Lian
Jul 15, 2009·Circulation·Eugene Braunwald
Jul 28, 2009·Journal of Molecular and Cellular Cardiology·Marcin DobaczewskiNikolaos G Frangogiannis
Aug 27, 2009·The Journal of Biological Chemistry·Shimin DongChunxiang Zhang

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Citations

Jun 30, 2011·Current Heart Failure Reports·Michael V G Latronico, Gianlugi Condorelli
Dec 5, 2012·Nature Reviews. Cardiology·Karl T WeberIvan C Gerling
Nov 11, 2011·Cardiovascular Research·S DangwalT Thum
Mar 6, 2012·Cardiovascular Research·Daniela FraccarolloJohann Bauersachs
Aug 11, 2012·Cardiovascular Research·Johann Bauersachs
Sep 22, 2011·Current Opinion in Rheumatology·Adam L Moyer, Kathryn R Wagner
Apr 28, 2012·Journal of Applied Physiology·Christopher L MendiasEvan B Lynch
Sep 14, 2012·Italian Journal of Pediatrics·Giuseppe Distefano, Pietro Sciacca
Jun 22, 2012·International Journal of Biological Sciences·Guangwen LongDao Wen Wang
Nov 6, 2012·Heart Failure Reviews·Ana Maria SeguraL Maximilian Buja
Dec 14, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S de JongH V M van Rijen
Jan 29, 2016·Expert Review of Cardiovascular Therapy·Ritin BombKarl T Weber
Jun 25, 2013·Journal of Shoulder and Elbow Surgery·Jonathan P GumucioChristopher L Mendias
Sep 11, 2012·The International Journal of Biochemistry & Cell Biology·Haihai LiangBaofeng Yang
Jun 15, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jonathan P GumucioChristopher L Mendias
Feb 19, 2014·Journal of Cellular and Molecular Medicine·Leni MoldovanMelissa Piper
Apr 26, 2014·International Journal of Experimental Pathology·Anna M Piccinini, Kim S Midwood
Oct 25, 2011·Journal of the American College of Cardiology·Arantxa GonzálezJavier Díez
Feb 6, 2013·Hypertension·Yao DaiJawahar L Mehta
Jul 23, 2011·Circulation Research·Johann Bauersachs, Thomas Thum
Aug 28, 2012·Circulation. Arrhythmia and Electrophysiology·Sophie CardinStanley Nattel
Aug 29, 2018·American Journal of Physiology. Endocrinology and Metabolism·Maryam SyedDamian G Romero
Jun 10, 2014·Oncogene·C WeigelO Popanda
Nov 14, 2013·Expert Review of Cardiovascular Therapy·François RoubilleJean-Claude Tardif
Jun 12, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Junliang WuZhengyong Li
Feb 9, 2017·Journal of Biomedical Science·Aleksandra GombozhapovaVyacheslav Ryabov
Nov 16, 2018·Medicina·Marlon E Cerf
May 3, 2015·Physiology·Victoria H J RobertsKevin L Grove
Mar 17, 2021·Journal of Cardiovascular Translational Research·Ni ZengZhi-Xin Shan
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Yanguo XinXiaojing Liu
Jul 3, 2021·Journal of Clinical Medicine·Federico MiglioreAlberto Cipriani

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