Regulation of myosin heavy chain antisense long noncoding RNA in human vastus lateralis in response to exercise training.

American Journal of Physiology. Cell Physiology
Clay E PandorfG R Adams

Abstract

Alterations to muscle activity or loading state can induce changes in expression of myosin heavy chain (MHC). For example, sedentary individuals that initiate exercise training can induce a pronounced shift from IIx to IIa MHC. We sought to examine the regulatory response of MHC RNA in human subjects in response to exercise training. In particular, we examined how natural antisense RNA transcripts (NATs) are regulated throughout the MHC gene locus that includes MYH2 (IIa), MYH1 (IIx), MYH4 (IIb), and MYH8 (Neonatal) in vastus lateralis before and after a 5-wk training regime that consisted of a combination of aerobic and resistance types of exercise. The exercise program induced a IIx to IIa MHC shift that was associated with a corresponding increase in transcription on the antisense strand of the IIx MHC gene and a decrease in antisense transcription of the IIa MHC gene, suggesting an inhibitory mechanism mediated by NATs. We also report that the absence of expression of IIb MHC in human limb muscle is associated with the abundant expression of antisense transcript overlapping the IIb MHC coding gene, which is the opposite expression pattern as compared with that previously observed in rats. The NAT provides a possible regulat...Continue Reading

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Citations

Oct 21, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Susanne N WijesingheSimon W Jones
Aug 3, 2021·American Journal of Alzheimer's Disease and Other Dementias·Yuchen He, Yi Qiang

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Methods Mentioned

BETA
X-ray
biopsy
PCR
electrophoresis
RNA-Seq

Software Mentioned

Ensembl
ImageQuant
JMP Pro
GraphPad Prism

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