Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems.

Free Radical Biology & Medicine
Ping Song, Ming-Hui Zou

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are ubiquitously produced in cardiovascular systems. Under physiological conditions, ROS/RNS function as signaling molecules that are essential in maintaining cardiovascular function. Aberrant concentrations of ROS/RNS have been demonstrated in cardiovascular diseases owing to increased production or decreased scavenging, which have been considered common pathways for the initiation and progression of cardiovascular diseases such as atherosclerosis, hypertension, (re)stenosis, and congestive heart failure. NAD(P)H oxidases are primary sources of ROS and can be induced or activated by all known cardiovascular risk factors. Stresses, hormones, vasoactive agents, and cytokines via different signaling cascades control the expression and activity of these enzymes and of their regulatory subunits. But the molecular mechanisms by which NAD(P)H oxidase is regulated in cardiovascular systems remain poorly characterized. Investigations by us and others suggest that adenosine monophosphate-activated protein kinase (AMPK), as an energy sensor and modulator, is highly sensitive to ROS/RNS. We have also obtained convincing evidence that AMPK is a physiological suppressor of NA...Continue Reading

References

Dec 1, 1994·Environmental Health Perspectives·B M Babior
Jan 12, 1996·The Journal of Biological Chemistry·D StapletonB E Kemp
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·E A KirkR C LeBoeuf
Sep 11, 2001·Biochemical and Biophysical Research Communications·S L ChoiJ Ha
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Nov 21, 2001·The Journal of Clinical Investigation·P A Barry-LaneM S Runge
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Mar 27, 2002·Circulation·Dan SorescuKathy K Griendling
Sep 7, 2002·Circulation Research·Puvi N SeshiahKathy K Griendling
Mar 22, 2003·Current Opinion in Cell Biology·Toren Finkel
Jul 5, 2003·American Journal of Physiology. Renal Physiology·Yves GorinHanna E Abboud
Jul 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bernard Lassègue, Roza E Clempus
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ali H Chamseddine, Francis J Miller

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Citations

Apr 27, 2013·Apoptosis : an International Journal on Programmed Cell Death·Xiao-Zhen ZhuoPing Song
May 22, 2013·Biochemical Pharmacology·Brice SidPedro Buc Calderon
Aug 14, 2012·Photochemistry and Photobiology·Flávia Mafra de LimaFlávio Aimbire
Nov 26, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Francesco CorradiRaffaele De Caterina
Mar 19, 2014·Cellular and Molecular Life Sciences : CMLS·Ping Song, Ming-Hui Zou
Feb 3, 2016·Frontiers in Pharmacology·Sara S Al DisiAli H Eid
Jan 17, 2016·Journal of Molecular and Cellular Cardiology·Evangelos P DaskalopoulosSandrine Horman
Jan 1, 2016·The International Journal of Biochemistry & Cell Biology·Ye DingPing Song
Mar 18, 2016·Antioxidants & Redox Signaling·Kumar Sharma
Apr 8, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Hao TangJing-Yan Han
Aug 26, 2015·Drug Development Research·Richard Seonghun Nho
Jun 24, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Ping QiuSu-Hua Pan
Jun 2, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chun-Yi LiChung-Hsuen Wu
Nov 4, 2016·Nature Reviews. Endocrinology·Lykke SylowThomas E Jensen
Oct 27, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sreenivas P Veeranki
Nov 10, 2017·Antioxidants·Amanda M EccardtJonathan S Fisher
Jun 19, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yan PiJing-Cheng Li
Aug 12, 2016·Journal of Korean Medical Science·Sun Mi ChoiYoung Whan Kim
Dec 30, 2015·Experimental Neurobiology·Geon Ha KimSujung Yoon
Jul 7, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Min Hu, Bo Liu
Jan 5, 2013·Journal of Applied Physiology·David Morales-AlamoJosé A L Calbet
Jul 12, 2020·The Journal of Biological Chemistry·Peng Zhao, Alan R Saltiel

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