Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders

Trends in Neurosciences
Pat LevittE M Powell

Abstract

Neurodevelopmental disorders typically have complex endophenotypes, which can include abnormalities in neuronal excitability, processing of complex information, as well as behaviors such as anxiety and social interactions. Converging experimental and clinical evidence suggests that altered interneuron development may underlie part of the pathophysiological process of such disorders. Consistent with this, mice with abnormal hepatocyte growth factor signaling exhibit disturbances in the development of specific interneuron subclasses that are paralleled by seizure activity and a complex behavioral phenotype. Mutations in molecules that regulate different aspects of interneuron development could provide the heterogeneity in genetic susceptibility that, when combined with environmental disturbances, results in a phenotypic spectrum that serves as the hallmark pathophysiology for autism, mental retardation, schizophrenia and other neurodevelopmental disorders.

References

Oct 9, 1992·Science·N A O'RourkeS K McConnell
Feb 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Blasi
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
Nov 14, 1997·Brain Research. Developmental Brain Research·C L AchimG K Michalopoulos
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·T U WooD A Lewis
Apr 9, 1999·Nature Neuroscience·F Maina, R Klein
May 13, 1999·Nature Neuroscience·H WichterleA Alvarez-Buylla
May 16, 2000·Biological Psychiatry·D BuxhoevedenM F Casanova
Apr 24, 2001·Molecular Psychiatry·A M PersicoUNKNOWN Collaborative Linkage Study of Autism
Aug 31, 2001·Nature Neuroscience·K Letinic, P Rakic
Sep 1, 2001·Behavior Genetics·L Gutknecht
Feb 13, 2002·Neurology·Manuel F CasanovaEmil Roy
Apr 19, 2002·Brain : a Journal of Neurology·Daniel P Buxhoeveden, Manuel F Casanova
May 25, 2002·Journal of Child Neurology·Shanti S ThirumalaiRicki Robinson
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Jul 12, 2002·Annals of Neurology·Manuel F CasanovaEmil L Roy
Dec 6, 2002·Cerebral Cortex·Vernon B Mountcastle
Feb 14, 2003·Current Neurology and Neuroscience Reports·Maria T Acosta, Phillip L Pearl
Mar 11, 2003·Annual Review of Neuroscience·Oscar Marín, John L R Rubenstein
Jul 10, 2003·Lancet Neurology·Roberto Tuchman, Isabelle Rapin
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Eric CourchesneNatacha Akshoomoff
Sep 2, 2003·Trends in Neurosciences·Tamás F Freund
Sep 4, 2003·The Journal of Cell Biology·Justin SturgeClare M Isacke
Sep 11, 2003·Developmental Neuroscience·Yangzhou DuCheryl F Dreyfus
Sep 11, 2003·Developmental Neuroscience·Elizabeth M PowellPat Levitt
Oct 2, 2003·Brain Research Bulletin·Paolo BrambillaFrancesco Barale

❮ Previous
Next ❯

Citations

Jul 26, 2011·Neural Plasticity·Pablo Méndez, Alberto Bacci
May 30, 2013·European Journal of Human Genetics : EJHG·Pedro Rodenas-CuadradoSonja C Vernes
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew W State
Aug 2, 2011·EMBO Molecular Medicine·Richard Holt, Anthony P Monaco
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel B CampbellPat Levitt
Nov 4, 2005·BMC Genetics·Steven P HamiltonJohn L R Rubenstein
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunyong MaAriel Agmon
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James E CrandallPradeep G Bhide
Apr 25, 2007·Molecular and Cellular Biology·Kelly A McClellanRuth S Slack
Feb 6, 2008·Cerebral Cortex·Renata Batista-BritoGord Fishell
May 15, 2008·Cerebral Cortex·Zdravko PetanjekMonique Esclapez
Jun 19, 2008·Environmental Health Perspectives·Mary E Gilbert, Li Sui
Jul 24, 2008·Journal of Autism and Developmental Disorders·Barbara L Thompson, Gregg D Stanwood
Aug 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiuxin LiuPasko Rakic
Aug 30, 2008·European Journal of Human Genetics : EJHG·Xudong LiuJeanette J A Holden
Nov 13, 2008·European Journal of Human Genetics : EJHG·Inês SousaUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Apr 3, 2009·The Journal of Clinical Investigation·Pat Levitt, Daniel B Campbell
Jan 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tamar Levav-RabkinHava M Golan
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ludovic TricoireChris J McBain
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Asif Mirza MaroofStewart A Anderson
Aug 14, 2010·Cerebral Cortex·Ethan M GoldbergBernardo Rudy
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shenfeng QiuGordon M G Shepherd
May 11, 2011·Cold Spring Harbor Perspectives in Biology·Anne E West, Michael E Greenberg
Dec 31, 2011·Journal of Autism and Developmental Disorders·Lauren CornewJ Christopher Edgar
Mar 1, 2013·Epilepsy Currents·Janice R Naegele
May 8, 2008·Current Neurology and Neuroscience Reports·Kyle P Johnson, Beth A Malow
Apr 20, 2007·Cerebral Cortex·Sylvie PoluchSharon L Juliano
Sep 1, 2012·Autism Research and Treatment·Charity OnorePaul Ashwood
Sep 11, 2008·Current Treatment Options in Neurology·Kyle P Johnson, Beth A Malow
May 5, 2012·Journal of Autism and Developmental Disorders·Jing-Qiong Kang, Gregory Barnes
Jul 12, 2005·Nature Neuroscience·Inma CobosJohn L R Rubenstein
Aug 21, 2009·World Journal of Pediatrics : WJP·Arianna BenvenutoPaolo Curatolo
Aug 9, 2006·Behavioral Neuroscience·Jonathan L BrigmanLawrence A Rothblat
May 20, 2009·The Journal of Cell Biology·Carlos MerinoPejmun Haghighi
May 24, 2011·Pediatric Clinics of North America·Ann M Reynolds, Beth A Malow

❮ Previous
Next ❯

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