Regulation of Neuronal Differentiation, Function, and Plasticity by Alternative Splicing

Annual Review of Cell and Developmental Biology
Elisabetta Furlanis, Peter Scheiffele

Abstract

Posttranscriptional mechanisms provide powerful means to expand the coding power of genomes. In nervous systems, alternative splicing has emerged as a fundamental mechanism not only for the diversification of protein isoforms but also for the spatiotemporal control of transcripts. Thus, alternative splicing programs play instructive roles in the development of neuronal cell type-specific properties, neuronal growth, self-recognition, synapse specification, and neuronal network function. Here we discuss the most recent genome-wide efforts on mapping RNA codes and RNA-binding proteins for neuronal alternative splicing regulation. We illustrate how alternative splicing shapes key steps of neuronal development, neuronal maturation, and synaptic properties. Finally, we highlight efforts to dissect the spatiotemporal dynamics of alternative splicing and their potential contribution to neuronal plasticity and the mature nervous system.

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Citations

Dec 28, 2018·The European Journal of Neuroscience·Harald WittePeter Scheiffele
Mar 12, 2020·Development·Laura RemesalNuria Flames
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Jan 29, 2022·Science Advances·Antonio Torres-MéndezManuel Irimia

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Methods Mentioned

BETA
antisense oligonucleotides
dissection
CLIP
immunoprecipitation
single-cell sequencing
PCR

Software Mentioned

RNAcompete

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

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