Regulation of neutrophils in type 2 immune responses

Current Opinion in Immunology
Lukas E M HeebOnur Boyman

Abstract

Type 2 immune responses contribute to the resistance to helminths and toxins as well as several physiological processes. Although they usually do not participate in type 2 immune responses, neutrophils have been shown in mice to enhance the anti-helminth response, but they also contribute to increased target tissue damage. Increased pathology and morbidity is also observed in type 2 immune-mediated disorders, such as allergic asthma, when neutrophils become a predominant subset of the infiltrate. How neutrophil recruitment is regulated during type 2 immune responses is now starting to become clear, with recent data showing that signaling via the prototypic type 2 cytokine interleukin-4 receptor mediates direct and indirect inhibitory actions on neutrophils in mice and humans.

Citations

Oct 9, 2019·Allergy·Thomas EiweggerJulia Upton
Jul 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Federica BottiglioneAdam F L Hurlstone
Aug 25, 2018·Cellular and Molecular Life Sciences : CMLS·Natalia Arenas-RamirezOnur Boyman
Jan 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sudeepta Kumar PandaFredrik Wermeling

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