PMID: 9422333Jan 9, 1998Paper

Regulation of neutrophils in ulcerative colitis by colonic factors: a possible mechanism of neutrophil activation and tissue damage

The Journal of Laboratory and Clinical Medicine
C E RobinsonA Keshavarzian

Abstract

The mucosal injury of active ulcerative colitis (UC) could involve enhanced migration and activation of neutrophils (PMNs). Because, in vitro, PMNs from patients with UC appear normal and are not therefore a likely cause for the enhancements, we hypothesized an abnormal colonic milieu. We previously found that factors in the UC colonic milieu markedly increase production of reactive oxygen species (ROS) by control PMNs. We now hypothesize that these factors also regulate PMN surface integrins, that regulation of UC PMNs is different than that of control PMNs, and that the integrin regulation is consistent with the ROS regulation. Using rectal dialysis, we sampled the colonic milieu in patients with active UC, in patients with inactive UC, and in control subjects. We monitored a key PMN adhesion molecule, CD11b. When control PMNs were tested, active UC rectal dialysate was almost as effective (+115%) as N-formyl-methionyl-leucyl-phenylalanine (+132%) in up-regulating CD11b. When inactive UC PMNs were tested, baseline CD11b was 50% higher than that for control PMNs. In contrast, rectal dialysates failed to up-regulate CD11b of inactive UC PMNs and in fact down-regulated CD11b. Preincubating control PMNs with UC rectal dialysates ...Continue Reading

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Citations

Apr 7, 2004·International Journal of Colorectal Disease·M BarolloG C Sturniolo
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aswin MangerichPeter C Dedon
Mar 12, 2008·Antioxidants & Redox Signaling·Michael J DaviesMartin D Rees
Jul 23, 2009·Antioxidants & Redox Signaling·Betty S van der VeenPeter Heeringa
Jan 15, 2014·Critical Reviews in Biochemistry and Molecular Biology·Dawit KidaneJoann B Sweasy
Nov 8, 2014·Journal of Evidence-based Complementary & Alternative Medicine·Jun TakanariTakahiro Maeda
Nov 19, 2008·Journal of Avian Medicine and Surgery·Wes A BaumgartnerMark A Mitchell
Mar 29, 2014·Fukushima Journal of Medical Science·Yasuo ShioyaHiromasa Ohira
Nov 12, 2014·World Journal of Gastroenterology : WJG·Rowann BowcuttSheena Margaret Cruickshank
May 14, 2017·The American Journal of Tropical Medicine and Hygiene·Manal Ibrahim KardoushMomar Ndao

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