PMID: 9442376Jan 27, 1998Paper

Regulation of NF-kappa B activation by MAP kinase cascades

Immunobiology
K Schulze-OsthoffS Wesselborg

Abstract

Transcription factor NF-kappa B plays a crucial role in the regulation of numerous genes involved in the inflammatory response and control of cell death. Activation of NF-kappa B is mediated through the phosphorylation of its inhibitory subunit I kappa B, followed by the subsequent degradation of I kappa B at the proteasome. A second level of control involves phosphorylation events of NF-kappa B in the cell nucleus. The kinases that regulate these processes are rather undefined. NF-kappa B activation is induced by a great variety of predominantly pathogenic and noxious stimuli. A similar spectrum of conditions triggers the activation of two mitogen-activated protein (MAP) kinase cascades, designated as the JNK and p38 kinase pathways. Several points of evidence suggest that MAP kinases can participate in the regulation of NF-kappa B transcriptional activity. Here, we will review very recent data demonstrating that both the JNK and the p38 pathways are involved in the activation of NF-kappa B in the cytoplasm as well as in modulation of its transactivating potential in the nucleus.

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Citations

Dec 26, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L XiangY B Kalin Zhang
Aug 2, 2002·Cryobiology·Jonathan R RobertsAndrew G Demaine
Oct 16, 2003·The Journal of Surgical Research·Babu V NaiduMichael S Mulligan
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Oct 16, 2003·Nutrition·A BlázovicsE Héthelyi
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Dec 17, 2005·Antioxidants & Redox Signaling·Guoxiang ShenAh-Ng Tony Kong
Feb 2, 2000·Current Opinion in Nephrology and Hypertension·A J Ingram, J W Scholey
May 1, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joe C Adams
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Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takahiro WatanabeJian-Dong Li

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