PMID: 9442373Jan 27, 1998Paper

Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability

Immunobiology
D Krappmann, C Scheidereit

Abstract

Transcription factor NF-kappa B must be released from cytoplasmic inhibitory molecules (I kappa Bs) in order to move to the nucleus and to activate its target genes. Little is known about the mechanisms regulating the maintenance of constitutive nuclear NF-kappa B in some cell-types and of sustained nuclear NF-kappa B activity after stimulation. Increased turnover has been implicated in the regulation of constitutive NF-kappa B activity in mature B cells. We therefore compared the turnover of I kappa B alpha and I kappa B beta in mature B cells and HeLa cells. Both proteins display a high turnover in B cells although I kappa B beta is considerably more stable than I kappa B alpha. The half-life of both inhibitors is increased in HeLa cells. In contrast, all other NF-kappa B/I kappa B molecules tested are relatively stable in both cell-types. The elevated turnover of endogenous I kappa B alpha in Namalwa cells is inhibited by a proteasome inhibitor and thus seems to be driven by the same degradation machinery as the slower turnover in non-B cells. Furthermore, we investigated the processes involved in persistent activation of NF-kappa B. TNF-alpha signaling leads to a rapid depletion of cellular I kappa B beta pools. I kappa B a...Continue Reading

Citations

Jul 6, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark A GrabinerTerry E Machen
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiajian Liu, David I Beller
Oct 20, 2005·The Journal of Biological Chemistry·Anneliese D ReckliesSuzanne M Bernier
Sep 26, 2020·Frontiers in Immunology·Miguel A ZarateClyde J Wright
Jan 21, 2012·Cellular and Molecular Life Sciences : CMLS·Karin HochrainerJosef Anrather
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·James E HarrisJon S Friedland
Apr 11, 2008·The EMBO Journal·Erika MathesGourisankar Ghosh
Jun 16, 2010·Histopathology·Silvia Darb-EsfahaniCarsten Denkert
Dec 23, 2016·Journal of Molecular Recognition : JMR·Mahmoud A Al-Sha'erMutasem O Taha
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·S B HaudekB P Giroir
Jun 2, 2000·Gastroenterology·R M Schmid, G Adler
Jun 19, 2008·Biochimica Et Biophysica Acta·Isabelle Jariel-EncontreMarc Piechaczyk

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