PMID: 9192179Jan 1, 1997Paper

Regulation of NF-kappa B and disease control: identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-kappa B activation

Current Topics in Cellular Regulation
T OkamotoJ P Merin

Abstract

We have identified novel signal transduction cascades in activating NF-kappa B, as well as its pathogenetic roles in various disease processes. By applying the basic knowledge obtained through these studies, we hope to find new therapeutic measures against currently incurable diseases such as hematogenic cancer cell metastasis, rheumatoid arthritis, and AIDS. We also propose a novel strategy in screening effective inhibitors against transcription factors. Elucidation of the cis-regulatory element for expression of pathogenetic genes and identification of the responsible transcription factor will not only facilitate the study of pathogenesis but will also promote the development of effective therapy. Recognition of control mechanisms of the NF-kappa B activation pathway has explained the therapeutic efficacy of various compounds with different pharmacologic actions. A similar strategy may be applicable for other inducible transcription factors. From the medical point of view, one of the purposes of these approaches is to find small molecular weight compounds that can be administered orally and that are effective in controlling gene expression of pathogenetic genes.

Citations

Jun 19, 2004·International Reviews of Immunology·Andras PerlKatalin Banki
Jul 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Kiyotaka TanakaTakashi Okamoto
Nov 7, 2007·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Takashi Okamoto, Atsushi Tsuchiya
May 21, 1999·The Journal of Biological Chemistry·J P YangT Okamoto
Sep 17, 2002·European Journal of Biochemistry·Naoko TakahashiTakashi Okamoto
Apr 22, 2008·Clinical and Experimental Immunology·L I FilippinR M Xavier
Dec 30, 2009·Arthritis and Rheumatism·Hiroshi OkamotoHisashi Yamanaka
Jun 6, 2008·Expert Review of Proteomics·Rachel Van DuyneFatah Kashanchi
Aug 20, 2016·Experimental Dermatology·Norihiro YoshizakiHitoshi Masaki
Sep 7, 2002·Antioxidants & Redox Signaling·Andras PerlKatalin Banki
Jun 22, 2010·The Journal of Biological Chemistry·Nan GaoTakashi Okamoto
Jan 27, 2006·Antimicrobial Agents and Chemotherapy·Ann Florence B VictorianoTakashi Okamoto
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takaomi SandaTakashi Okamoto
May 1, 2002·Pathologie-biologie·C Bottex-GauthierD R Vidal
Nov 7, 2002·Free Radical Biology & Medicine·Jordi BoadaJordi Bermúdez
Feb 5, 2003·Biochemical and Biophysical Research Communications·Xu JiangTakashi Okamoto
Apr 3, 2003·Biochemical and Biophysical Research Communications·Futoshi TeranishiTakashi Okamoto

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