PMID: 16626297Apr 22, 2006Paper

Regulation of NF-kappaB function

Biochemical Society Symposium
Kirsteen J Campbell, Neil D Perkins

Abstract

In the 20 years since its discovery, research into the NF-kappaB (nuclear factor-kappaB) family of transcription factors has revealed an amazing diversity of functions. NF-kappaB proteins are regulators of the immune, inflammatory, stress, proliferative and apoptotic responses of a cell to a very large number of different stimuli. NF-kappaB complexes can be found in all cell types, indicating that the number of different contexts in which NF-kappaB can become induced is enormous. Moreover, many reports suggest apparently opposing or contradictory functions for NF-kappaB. It is clear that it is not simply enough to understand the pathways leading to nuclear localization and DNA binding of NF-kappaB subunits. It is also important that we comprehend the regulation of NF-kappaB subunit functionality if we are to understand the NF-kappaB pathway as a whole. These issues include the mechanisms controlling the specificity and timing of genes regulated by NF-kappaB under particular circumstances. They also include the reasons why NF-kappaB subunits can sometimes repress rather than activate transcription and how the NF-kappaB response is integrated with other important transcription factor pathways in the cell, such as the induction of...Continue Reading

Citations

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