Regulation of nicotinic acetylcholine receptors in Alzheimer׳s disease: a possible role of chaperones

European Journal of Pharmacology
Saeed Sadigh-EteghadShirin Babri

Abstract

Nicotinic acetylcholine receptors (nAChRs) seem to play an integral role in the progress and/or prevention of Alzheimer׳s diseases (AD). Functional abnormalities and problems in biogenesis and trafficking of nAChRs are two major culprits in AD; on the other hand, chaperones modulate post-translational changes in nAChRs. Moreover, they indirectly regulate nAChRs by controlling AD-related proteins such as tau and amyloid beta (Aβ). In this review, we go through recent studies which are showing that chaperones modulate the expression of nAChRs in a subtype-specific manner and explain how AD progress is affected by nAChRs chaperoning.

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Citations

Jul 28, 2015·Biochemical Pharmacology·Qing Cheng, Jerrel L Yakel
Jun 6, 2016·Journal of Neural Transmission·Saeed Sadigh-EteghadMahnaz Talebi
Mar 16, 2017·British Journal of Pharmacology·Arianna CrespiCecilia Gotti
Jun 7, 2017·Reviews in the Neurosciences·Alireza MajdiSaeed Sadigh-Eteghad
Jun 11, 2016·Journal of Neuroscience Research·Alireza MajdiSiamak Reyhani-Rad
May 20, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chenghuan SongHao Wang

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