PMID: 9447227Feb 3, 1998Paper

Regulation of nitric oxide production by rat alveolar macrophages in response to silica exposure

Journal of Toxicology and Environmental Health. Part a
L J HuffmanV Castranova

Abstract

In the present study, it was confirmed that in vivo exposure of rats to silica significantly increases nitric oxide (NO) production by bronchoalveolar lavage cells (BALC), a population of cells that includes alveolar macrophages. Possible mechanisms whereby NO production could be upregulated by rat alveolar macrophages following silica exposure were examined to determine if there is a direct effect of silica on alveolar macrophage NO production or if other factors are involved. BALC were obtained from normal male rats and cultured for 2 h. Nonadherent cells were then removed and the enriched alveolar macrophage cell populations were exposed to test agents for 18-20 h. Media nitrate and nitrite (NOx) concentrations were used to assess NO production and, in some cases, inducible NO synthase mRNA levels were indexed. In vitro exposure to silica (0.1-100 micrograms/ml) had no significant effect on basal NO levels. Furthermore, NO generation was not additionally increased above levels induced by interferon gamma (IFN), lipopolysaccharide (LPS), or other cytokines during simultaneous incubations with silica and IFN, a 2-h pretreatment with silica followed by IFN, or preincubation with IFN, LPS, and/or other cytokines before the addit...Continue Reading

Citations

Jun 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Amy K MadlDennis J Paustenbach
Jan 6, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Maureen R Gwinn, Val Vallyathan
Sep 23, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M GulumianJ Murray
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Mirjana PoljakovicSidney M Morris
May 19, 2009·American Journal of Respiratory Cell and Molecular Biology·Lester Kobzik
Dec 8, 2004·Environmental Health Perspectives·K Murali Krishna RaoVince Castranova
Mar 24, 2004·Redox Report : Communications in Free Radical Research·Patti C Zeidler, Vincent Castranova
Feb 8, 2014·Human & Experimental Toxicology·D S El-AgamyE M Ammar
Feb 1, 2018·International Journal of Molecular Sciences·Yoshimi KobayashiHirohisa Takano
Oct 28, 1998·Environmental Health Perspectives·V CastranovaR D Dey
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philippe JuvinMichel Aubier
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dale W PorterVincent Castranova
Dec 13, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dale W PorterVincent Castranova

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