Regulation of nitric oxide synthase gene expression by cytokines

Journal of Cardiac Failure
M YokoyamaY Kawahara

Abstract

Evidence is presented that not only macrophage type of NO synthase but also endothelial constitutive type of NO synthase genes are regulated by a variety of exogenous stimuli including cytokines. It is possible that pathophysiological concentrations of TNF-alpha noted in some patients with congestive heart failure may be sufficient to decrease levels for the constitutive form of NO synthase and increase those for the inducible form of NO synthase. Interestingly, chronic exercise in dogs was demonstrated to increases coronary vascular NO production and steady-state mRNA levels of ecNO synthase. Endogenous NO plays a crucial role in modulating vascular tone and inhibiting interactions of the vessel wall with circulating blood elements such as platelets, monocytes and neutrophils. It is possible that alterations in its synthesis or activity may play an important role in some cardiovascular disorders including congestive heart failure. Further studies of the pathophysiological significance of NO in specific experimental and clinical settings of congestive heart failure may provide a basis for improved therapeutic measures to enhance the synthesis or effect of endogenous NO, or to supplement its activity with exogenous NO donors or ...Continue Reading

References

Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jan 1, 1995·Annual Review of Physiology·O W Griffith, D J Stuehr
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·N InoueD G Harrison
Apr 21, 1994·The New England Journal of Medicine·L G Lange, G F Schreiner
May 1, 1994·Circulation·W H Barry
Oct 1, 1993·Journal of the American College of Cardiology·C B Treasure, R W Alexander
Mar 27, 1996·Biochemical and Biophysical Research Communications·S MikamiM Yokoyama

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Citations

Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·S M WildhirtB Reichart
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·S M WildhirtB Reichart
Sep 27, 2001·Endothelium : Journal of Endothelial Cell Research·P BarbeauB Gutin
Jun 11, 2011·International Journal of Immunopathology and Pharmacology·I AltorjayK Palatka
Feb 19, 2002·Kidney International·Christopher M ReillyGary S Gilkeson
Dec 2, 2008·Cytokine & Growth Factor Reviews·James E McLaren, Dipak P Ramji

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