Regulation of noradrenaline overflow in rat cerebral cortex by prostaglandin E2

British Journal of Pharmacology
K Hillier, W W Templeton

Abstract

1 The effects of prostaglandin E2 (PGE2), PGF2 alpha and PGI2 and of inhibitors of prostaglandin synthesis and action, on the K+-evoked [3H]-noradrenaline ([3H]-NA) overflow from rat cerebral cortex slices have been investigated. 2 PGE2 reduced, while indomethacin (a prostaglandin synthesis inhibitor) or SC 19220 (a prostaglandin receptor antagonist) increased, the evoked overflow compared with controls. 3 The inhibition of [3H]-NA overflow by PGE2 was dose-dependently antagonized by SC 19220. 4 The results indicate that PGE2 modulates NA release in rat cerebral cortex in vitro.

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Citations

Jun 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
Oct 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C AllgaierG Hertting
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Jan 1, 1982·General Pharmacology·K Hillier, W W Templeton
Jan 1, 1985·General Pharmacology·E K Chiu, J S Richardson
Mar 1, 1994·General Pharmacology·K H al-ZadjaliS E Ohia
May 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N OnoH Kamiya
Jan 14, 1982·Brain Research·G FeuersteinD M Jacobowitz
Jan 1, 1990·Annals of the New York Academy of Sciences·G HerttingC Allgaier
Nov 1, 1985·Journal of Neurosurgery·J B Leslie, W D Watkins
Jul 1, 1990·Journal of Neurochemistry·T Shimizu, L S Wolfe
Jan 1, 1989·Annals of the New York Academy of Sciences·A I Barkai, L R Murthy
Jun 15, 1984·Brain Research·S Divinetz RomeroT L Yaksh

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