Regulation of norepinephrine transport system by angiotensin II in neuronal cultures of normotensive and spontaneously hypertensive rat brains

Endocrinology
D LuMohan K Raizada

Abstract

Brain angiotensin II (Ang II) plays a key role in blood pressure control in part by interacting with catecholamines (CA) and by stimulation of sympathetic pathways. The significance of Ang-CA interaction is further heightened by the presence of a hyperactive brain Ang II system in spontaneously hypertensive (SH) rat, a genetic model for essential hypertension. Neuronal cells in primary culture from the hypothalamus-brainstem that mimic in vivo situations in so far as many cellular actions of Ang II are concerned, have been used in the present study to elucidate Ang II regulation of CA by determining its cellular action on the norepinephrine transporter (NET) system. Ang II causes both acute and chronic stimulation of [3H]-norepinephrine (NE) uptake in neuronal cultures of Wistar Kyoto (WKY) rat brain. Acute stimulation begins as early as 5 min, reaches maximal levels in about 30 min in the presence of 100 nM Ang II, and is blocked by losartan, a specific antagonist for AT1 receptor subtype. In addition, this acute stimulation appears to be a posttranscriptional event and does not involve protein kinase C (PKC) or NET gene transcription. Chronic stimulation of [3H]-NE uptake by Ang II persists throughout the duration of Ang II i...Continue Reading

Citations

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·S N IyerM K Raizada
Oct 8, 2009·Journal of Hypertension·Amy MilstedMonte E Turner
Dec 21, 2010·BMC Systems Biology·Gregory M MillerRajanikanth Vadigepalli
Jul 28, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J P VoigtH Fink
Feb 11, 2004·Progress in Biophysics and Molecular Biology·S KasparovJ F R Paton
May 13, 1999·Molecular Neurobiology·E M RichardsC Sumners
Dec 31, 2003·Molecular and Cellular Neurosciences·Valentina SavchenkoRandy D Blakely
Dec 26, 2006·Molecular and Cellular Neurosciences·Uhna Sung, Randy D Blakely
May 29, 2003·British Journal of Pharmacology·Shereeni J Veerasingham, Mohan K Raizada
Mar 17, 2006·Journal of Neurochemistry·Prashant Mandela, Gregory A Ordway
May 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chanran K GantaMichael J Kenney
Jul 14, 1998·The Journal of Cell Biology·D LuM K Raizada
Nov 1, 1996·Japanese Journal of Pharmacology·S Kitayama, T Dohi

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