May 31, 2011

Regulation of nucleocytoplasmic transport in skeletal muscle

Current Topics in Developmental Biology
Monica N HallGrace K Pavlath

Abstract

Proper skeletal muscle function is dependent on spatial and temporal control of gene expression in multinucleated myofibers. In addition, satellite cells, which are tissue-specific stem cells that contribute critically to repair and maintenance of skeletal muscle, are also required for normal muscle physiology. Gene expression in both myofibers and satellite cells is dependent upon nuclear proteins that require facilitated nuclear transport. A unique challenge for myofibers is controlling the transcriptional activity of hundreds of nuclei in a common cytoplasm yet achieving nuclear selectivity in transcription at specific locations such as neuromuscular synapses and myotendinous junctions. Nucleocytoplasmic transport of macromolecular cargoes is regulated by a complex interplay among various components of the nuclear transport machinery, namely nuclear pore complexes, nuclear envelope proteins, and various soluble transport receptors. The focus of this review is to highlight what is known about the nuclear transport machinery and its regulation in skeletal muscle and to consider the unique challenges that multinucleated muscle cells as well as satellite cells encounter in regulating nucleocytoplasmic transport during cell diffe...Continue Reading

  • References
  • Citations4

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations4

Citations

Mentioned in this Paper

Muscle Physiology
Nuclear Proteins
Muscle Cells
Complex (molecular entity)
Protoplasm
Transcription, Genetic
Nuclear Transport
Soleus Muscle Structure
Cell Nucleus
Gene Expression

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Traffic
B Ossareh-NazariC Dargemont
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
M MarelliJ D Aitchison
Frontiers in Bioscience (Elite Edition)
Gabi Shefer, Dafna Benayahu
© 2020 Meta ULC. All rights reserved