PMID: 8612639Mar 1, 1996Paper

Regulation of olfactory signalling via cGMP-dependent protein kinase

European Journal of Biochemistry
C KronerH Breer

Abstract

Strong odor stimuli elicit a slow and sustained increase of the cGMP concentration in isolated rat olfactory cilia. Elevated cGMP levels appear to attenuate the primary response to odorant stimulation. Incubating cilia with membrane-permeable cGMP derivates caused a significantly reduced cAMP signal in response to odorant stimulation. This inhibitory effect was mimicked by 8-(4-chlorophenlythio)-cGMP, a selective activator of cGMP-activated protein kinases; in contrast, a selective inhibitor, [8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphorothioate] of cGMP kinases enhanced the reactivity to odorant stimulation. The data suggest that the responsiveness of olfactory sensory cells is governed by a cGMP-dependent protein kinase. Western-blot analysis using subtype-specific antibodies indicated that cytosolic type-I cGMP kinase, but not the membrane-associated type-II cGMP kinase, is expressed in olfactory sensory neurons.

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Citations

Sep 1, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Y Ben-Shahar
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Aug 10, 2012·Physiology·Claudia Lodovichi, Leonardo Belluscio
Jan 7, 2021·Cell and Tissue Research·Claudia Lodovichi
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Jun 13, 1996·Biochimica Et Biophysica Acta·C KronerH Breer
Aug 29, 2021·BMC Biology·Simona Francia, Claudia Lodovichi

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