Regulation of osteocalcin production and bone resorption by 1,25-dihydroxyvitamin D3 in mouse long bones: interaction with the bone-derived growth factors TGF-beta and IGF-I

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
A StaalJ P van Leeuwen

Abstract

Bone cells produce multiple growth factors that have effects on bone metabolism and can be incorporated into the bone matrix. Interplay between these bone-derived growth factors and calciotropic hormones has been demonstrated in cultured bone cells. The present study was designed to extend these observations by examining the interactions between either transforming growth factor-beta (TGF-beta) or insulin-like growth factor-I (IGF-I) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in a mouse long bone culture model with respect to osteocalcin production and bone resorption. In contrast to the stimulation in rat and human, in the fetal mouse long bone cultures, 1,25(OH)2D3 caused a dose-dependent inhibition of osteocalcin production. Both the osteocalcin content in the culture medium and in the extracts of the long bones was reduced by 1,25(OH)2D3. This effect was not specific for fetal bone because 1,25(OH)2D3 also reduced osteocalcin production by the neonatal mouse osteoblast cell line MC3T3. TGF-beta inhibited whereas IGF-I dose-dependently increased osteocalcin production in mouse long bones. The combination of TGF-beta and 1,25(OH)2D3 did not result in a significantly different effect compared with each of these compounds alone...Continue Reading

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Citations

Mar 8, 2014·BoneKEy Reports·Marjolein van Driel, Johannes P T M van Leeuwen
Jan 17, 2013·Cell & Bioscience·Shimpei Kasagi, Wanjun Chen
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y TanakaY Minami
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Kathy Keiver, Joanne Weinberg
May 2, 2014·Frontiers in Physiology·Jeroen van de Peppel, Johannes P T M van Leeuwen
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Stefania BeniniKatia Scotlandi
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B J MehraraM T Longaker
May 17, 2012·Clinical Sarcoma Research·Fergal C Kelleher, David M Thomas
Oct 17, 2019·International Journal of Molecular Sciences·Alexander PopovVirginie Sottile
Jul 3, 2007·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·W L Holzemer, L R Uys
Jan 1, 1998·Journal of Cellular Biochemistry·Barry S Komm, Peter V N Bodine
Aug 15, 2003·Immunological Investigations·Cheorl-Ho KimYoung-Guk Park
Sep 24, 2019·Cytokine & Growth Factor Reviews·Caterina LiciniMonica Mattioli-Belmonte

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