Abstract
P300 and HDAC1 can be involved in the development of various liver diseases by regulating gene transcription. Endoplasmic reticulum stress (ERS) is one of the main pathways of apoptosis and is activated during inflammatory responses, but the roles of P300 and HDAC1 in ERS in antituberculosis drug-induced liver injury (ADLI) are not clear. This study confirms that isoniazid can change the states of P300 and HDAC1 in HL-7702 hepatocyte metabolism and induce ERS, causing hepatocyte injury and apoptosis. When combined with C646, however, P300 can be reduced. HL-7702 cells were flattened, and the cytoplasm became crinkled. To a certain extent, ERS was relieved, but hepatocytes suffered worse damage, and the rate of cell apoptosis markedly increased. When MS-275 was applied, HDAC1 level was increased, cell fusion appeared, and fluorescence intensity of endoplasmic reticulum was weakened. In addition, ERS was aggravated, but liver injury was relieved, and the apoptosis rate significantly decreased. Therefore, alteration of P300 and HDAC1 status and ERS are involved in ADLI, and changes in P300 and HDAC1 can regulate ERS and then affect cell damage.
References
Jan 15, 1993·Cell·D Y LeeA P Wolffe
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W M WongC L Lai
May 19, 2005·Molecular and Cellular Biology·Peter BaumeisterAmy S Lee
Jun 15, 2005·Annual Review of Biochemistry·Martin Schröder, Randal J Kaufman
Feb 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Yuren WeiMichael J Pagliassotti
Sep 18, 2007·The Biochemical Journal·Nagma KhanMaxwell Sehested
Feb 22, 2008·Methods in Molecular Biology·Tae-Young Roh, Keji Zhao
Apr 29, 2008·Advances in Experimental Medicine and Biology·Sharmila Shankar, Rakesh K Srivastava
Apr 30, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chao-Chi HoKwen-Tay Luh
Jun 9, 2010·The Journal of Pathology·Tarik AsselahRichard Moreau
Aug 20, 2011·Science·Brooke M Gardner, Peter Walter
May 9, 2012·Archives of Medical Research·Ling YuXia Chen
Jul 21, 2012·The Journal of Biological Chemistry·Ling HeFredric E Wondisford
Jan 4, 2013·Fibrogenesis & Tissue Repair·Katrien Van BenedenLeo A van Grunsven
Jul 31, 2013·PloS One·Andrea W SchramH Th Marc Timmers
Aug 7, 2013·Gastroenterology·Susan K MurphyAnna Mae Diehl
Mar 5, 2014·Biological Trace Element Research·Xiuli ZhangZhi-Hong Chi
Feb 25, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M H LevineW W Hancock
Jun 27, 2015·The Canadian Journal of Cardiology·Xi ZhaSidong Xiong
May 1, 2016·The Journal of Biological Chemistry·Sara K YoungRonald C Wek
Jun 21, 2016·Scientific Reports·Abigail D G NunnAnnika Enejder
Aug 25, 2016·Intervirology·Nimisha Harshadrai Bhoola, Anna Kramvis
Mar 10, 2017·Cellular and Molecular Gastroenterology and Hepatology·Anne S HenkelRichard M Green
Mar 10, 2017·PloS One·Ikuko TakaharaKazuhiko Nakao
Mar 16, 2017·The Pan African Medical Journal·Omaima El BouazziRachid Bengueddour
Sep 28, 2017·Gene·Xin ZhouAixiu Qiao
Nov 29, 2017·Oncotarget·Na LiuKin-Sang Cho
Feb 9, 2018·Oncotarget·Tao ZhangFeng Zhang