Regulation of p53--insights into a complex process

Critical Reviews in Biochemistry and Molecular Biology
Karen A Boehme, Christine Blattner

Abstract

The p53 protein is one of the most important tumor suppressor proteins. Normally, the p53 protein is in a latent state. However, when its activity is required, e.g. upon DNA damage, nucleotide depletion or hypoxia, p53 becomes rapidly activated and initiates transcription of pro-apoptotic and cell cycle arrest-inducing target genes. The activity of p53 is regulated both by protein abundance and by post-translational modifications of pre-existing p53 molecules. In the 30 years of p53 research, a plethora of modifications and interaction partners that modulate p53's abundance and activity have been identified and new ones are continuously discovered. This review will summarize our current knowledge on the regulation of p53 abundance and activity.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J BaudierJ J Lawrence
Sep 1, 1984·Molecular and Cellular Biology·W Maltzman, L Czyzyk
Aug 4, 1995·The Journal of Biological Chemistry·J ZhaoR J Collier
Jun 1, 1995·Nature Genetics·X W WangB G Taffe
Jul 1, 1993·Molecular and Cellular Biology·J ChenA J Levine
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MaheswaranD A Haber
Oct 10, 1996·Gene·S N JonesA Bradley
Mar 1, 1997·Genes & Development·L JayaramanC Prives
May 15, 1997·Nature·Y HauptM Oren
May 15, 1997·Nature·M H KubbutatK H Vousden
Dec 31, 1997·Molecular and Cellular Biology·L J KoZ Q Pan
Jan 10, 1998·The Journal of Biological Chemistry·T Léveillard, B Wasylyk
Dec 11, 1997·Oncogene·M C HuY P Wang
Mar 21, 1998·Genes & Development·L JayaramanC Prives
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·H LuA J Levine
Jun 25, 1998·Molecular and Cellular Biology·C ScottoJ Baudier
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KamijoC J Sherr
Sep 23, 1998·Genes & Development·K SakaguchiE Appella
Nov 26, 1998·The Journal of Biological Chemistry·P F LambertJ N Brady
Jan 30, 1999·Genes & Development·R S TibbettsR T Abraham
Feb 18, 1999·Molecular and Cellular Biology·M AshcroftK H Vousden
Mar 20, 1999·The Journal of Biological Chemistry·R V SionovY Haupt
Apr 23, 1999·The Journal of Biological Chemistry·C HuangZ Dong
Apr 28, 1999·FEBS Letters·S TanimuraM Ohtsubo
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·W Tao, A J Levine
Jun 11, 1999·Genes & Development·E A SpillareC C Harris
Sep 15, 1999·Genes & Development·R MaestroG J Hannon
Nov 24, 1999·European Journal of Biochemistry·C GötzM Montenarh
Nov 24, 1999·The EMBO Journal·M S RodriguezR T Hay

❮ Previous
Next ❯

Citations

Aug 4, 2011·Nature Reviews. Urology·Stephen MitchellAnup Patel
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Roman KulikovChristine Blattner
Oct 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chul Won LeePeter E Wright
Jun 2, 2010·The Journal of Experimental Medicine·Karen J HoSeth J Karp
Jan 26, 2012·Blood·Zijun Y Xu-MonetteKen H Young
Aug 13, 2010·Journal of Experimental & Clinical Cancer Research : CR·Cheng-Jeng TaiMing-Chung Jiang
Nov 3, 2012·PloS One·Tobias BrandtDmitry B Veprintsev
Sep 29, 2011·World Journal of Biological Chemistry·Valeriya Solozobova, Christine Blattner
Aug 12, 2014·Ultrasonics Sonochemistry·Xiao-dong LiuPu-Yan Chen
Feb 9, 2012·Expert Opinion on Therapeutic Targets·Stian Knappskog, Per Eystein Lønning
Oct 28, 2016·Oncogene·S ElabdC Blattner
Oct 16, 2012·Nuclear Medicine and Biology·Amanda J WeeksDaniel R Lloyd
Dec 14, 2011·Progress in Retinal and Eye Research·Mohammadali AlmasiehAdriana Di Polo
Sep 21, 2011·Advances in Biological Regulation·Jacqueline BoultwoodJames S Wainscoat
Sep 21, 2011·Molecular and Cellular Endocrinology·Jonathan D WassermanDavid Malkin
Jun 28, 2011·Gastroenterology·A Kathleen McClendonErik S Knudsen
Jun 15, 2010·Experimental Cell Research·Valeriya Solozobova, Christine Blattner
Sep 1, 2015·Critical Reviews in Oncology/hematology·Ting-Xun LuJian-Yong Li
May 29, 2015·Journal of Cellular Biochemistry·Elizabeth ChippsM Rafiq Islam
Oct 30, 2012·Journal of Molecular Biology·Marco RetzlaffJohannes Buchner
Dec 20, 2011·Journal of Molecular Biology·Hyunjung KimWoojin An
Sep 29, 2011·Mechanisms of Ageing and Development·Artur Zajkowicz, Marek Rusin
May 20, 2015·Brain : a Journal of Neurology·Yashashree JoshiSimone Di Giovanni
Jun 16, 2015·Cell & Bioscience·Christine Blattner
Dec 30, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Orçun ToptaşKayhan Başak
May 24, 2016·Cell Cycle·Rachel BeckermanCarol Prives
Nov 12, 2016·Cold Spring Harbor Perspectives in Medicine·Neil T Pfister, Carol Prives
Mar 3, 2015·Oncogene·P ZhangC Blattner
Jul 26, 2018·Stem Cells and Development·Melissa RodriguesLiborio Stuppia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.