PMID: 9552351Jan 1, 1995Paper

Regulation of p70s6k/p85s6k and its role in the cell cycle

Progress in Cell Cycle Research
R B Pearson, G Thomas

Abstract

Two to three-fold increases in the rate of protein synthesis are required both to enter the G1 phase of the cell cycle from G0 and to proceed to S phase in response to growth factors and mitogens. This increase is in part regulated via multiple phosphorylation of the 40S ribosomal protein S6 by the mitogen-stimulated p70s6k/p85s6k. At the protein synthesis level this event appears to be involved in specifically increasing the efficiency of translation of a family of essential mRNAs containing a polypyrimidine tract at their 5' transcriptional start site. The activation of p70s6k/p85s6k and maintenance of its activity throughout G1 is controlled via multiple phosphorylation events mediated by a complex signalling network acting on distinct sets of phosphorylation sites.

Citations

Jul 21, 2009·Expert Opinion on Therapeutic Targets·Xianfeng Frank Zhao, Ronald B Gartenhaus
Aug 2, 2003·Clinical and Experimental Pharmacology & Physiology·R D HannanY Brandenburger
Sep 28, 2004·The Plant Journal : for Cell and Molecular Biology·Jarmo SchraderRishikesh P Bhalerao
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Wen LongZhenqi Liu
Aug 4, 2009·Nature Neuroscience·Emma PuighermanalAndrés Ozaita
Dec 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Zhenqi LiuEugene J Barrett
Mar 5, 2004·American Journal of Physiology. Endocrinology and Metabolism·Håkan K R KarlssonEva Blomstrand
Mar 25, 2004·American Journal of Physiology. Endocrinology and Metabolism·Zhenqi LiuEugene J Barrett
May 19, 2007·The Journal of Biological Chemistry·Robert J SouthgateMark A Febbraio

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