Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling

Oncology Letters
Yu GanYan Lei

Abstract

Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosphatase and tensin homolog (PTEN)-positive 22Rv1 cells than PTEN-negative LNCaP cells. Knockdown of PTEN in 22Rv1 cells resulted in increased resistance to paclitaxel and impaired the induction of maspin expression by paclitaxel. Overexpression of PTEN sensitized LNCaP cells to paclitaxel treatment and increased maspin induction by paclitaxel. Furthermore, knocking down maspin abrogated PTEN-induced paclitaxel sensitivity in LNCaP cells. PTEN/maspin signaling may be important for regulating the susceptibility to paclitaxel in prostate cancer.

References

Feb 22, 1979·Nature·P B SchiffS B Horwitz
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S RamaswamyW R Sellers
Sep 29, 1999·Cancer Chemotherapy and Pharmacology·L G WangD R Budman
Feb 2, 2000·Nature Medicine·M ZhangN Bouck
Feb 29, 2000·The Journal of Biological Chemistry·Z ZouS Srivastava
Jun 15, 2004·The Biochemical Journal·Nick R Leslie, C Peter Downes
Oct 8, 2004·The New England Journal of Medicine·Jose D Debes, Donald J Tindall
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Apr 4, 2007·Annals of the New York Academy of Sciences·Su-Hyeong KimYong-Sang Song
Feb 6, 2009·Gynecologic Oncology·Dagmara Klasa-MazurkiewiczJanusz Emerich
Feb 26, 2009·Breast Cancer Research : BCR·Satoshi NakayamaNaoto T Ueno
Mar 11, 2010·Biochemical and Biophysical Research Communications·Dong-Jun PengGen Sheng Wu
Apr 6, 2017·Frontiers in Pharmacology·Nadeem BilaniWassim Abou-Kheir

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