Regulation of parathyroid function in chronic renal failure

Journal of Bone and Mineral Metabolism
Mariano RodriguezYolanda Almaden

Abstract

This review summarizes the factors involved in the development of hyperparathyroidism secondary (2nd-HPTH) to chronic kidney disease (CKD). Calcium and calcitriol act on their respective specific parathyroid cell receptors to inhibit parathyroid function. As well as the well-known effect of calcium and calcitriol on parathyroid cell function, there is experimental work that demonstrates that phosphate, changes in pH, PTHrP, estrogens, and some cytokines also have an effect on PTH secretion. These factors are relevant in patients with chronic kidney disease. However, low calcium, vitamin D deficiency, and an accumulation of phosphate due to the decrease in renal function are the main pathogenic factors involved in the pathogenesis of 2nd-HPTH in CKD patients.

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Citations

Dec 1, 2009·Kidney International. Supplement·Vincent M BrandenburgMarkus Ketteler
Jul 20, 2007·European Journal of Clinical Investigation·B Kestenbaum, V Belozeroff
Nov 15, 2011·Histopathology·Nadia TalatKlaus-Martin Schulte
Dec 3, 2014·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Daniele Pinto VasconcelosAlexandre Braga Libório
Mar 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Paolo Raggi, Michael Kleerekoper
Apr 2, 2011·Clinical Journal of the American Society of Nephrology : CJASN·John CunninghamMariano Rodriguez
Jul 21, 2010·Mutagenesis·Megan J OsmondElizabeth T Snow
Nov 27, 2021·Experimental Gerontology·Sarah J WherryWendy M Kohrt

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