Regulation of peroxisome dynamics by phosphorylation

Biochimica Et Biophysica Acta
Silke OeljeklausBettina Warscheid

Abstract

Peroxisomes are highly dynamic organelles that can rapidly change in size, abundance, and protein content in response to alterations in nutritional and other environmental conditions. These dynamic changes in peroxisome features, referred to as peroxisome dynamics, rely on the coordinated action of several processes of peroxisome biogenesis. Revealing the regulatory mechanisms of peroxisome dynamics is an emerging theme in cell biology. These mechanisms are inevitably linked to and synchronized with the biogenesis and degradation of peroxisomes. To date, the key players and basic principles of virtually all steps in the peroxisomal life cycle are known, but regulatory mechanisms remained largely elusive. A number of recent studies put the spotlight on reversible protein phosphorylation for the control of peroxisome dynamics and highlighted peroxisomes as hubs for cellular signal integration and regulation. Here, we will present and discuss the results of several studies performed using yeast and mammalian cells that convey a sense of the impact protein phosphorylation may have on the modulation of peroxisome dynamics by regulating peroxisomal matrix and membrane protein import, proliferation, inheritance, and degradation. We fu...Continue Reading

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Citations

Feb 7, 2016·Biochimica Et Biophysica Acta·Ralf Erdmann
Aug 19, 2020·Biomolecules·Anastasija PlettNicole Linka
Aug 28, 2020·The Journal of Cell Biology·Koichiro YamashitaYukio Fujiki
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Andreas SchummerBettina Warscheid
Feb 6, 2021·Advances in Biological Regulation·Sara Wong, Lois S Weisman
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
Sep 3, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Terence InfantShirisha Nagotu

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