PMID: 6988218Mar 1, 1980Paper

Regulation of phosphatidylethanolamine methyltransferase level by myo-inositol in Saccaromyces cerevisiae

European Journal of Biochemistry
S Yamashita, A Oshima

Abstract

1. A conditional choline auxotroph was isolated. The growth of this mutant was markedly inhibited by the addition of a low concentration of myo-inositol to the culture medium. The growth inhibition was completely prevented by the addition of choline. 2. When this mutant cell was grown in the presence of myo-inositol, the intracellular level of phosphatidylethanolamine methyltransferase was very low, whereas in the cell grown in the absence of myo-inositol the enzyme level was normal. The addition of myo-inositol to the cell grown in the absence of myo-inositol caused a marked decrease in the methyltransferase level. 3. The reduction in phosphatidylethanolamine methyltransferase level by myo-inositol also occurred in various wild type strains of Saccharomyces cerevisiae. 4. The decreased methyltransferase activity was restored by the removal of myo-inositol from the culture medium. The restoration of the enzyme level was completely abolished by cycloheximide. Thus, it was shown that protein synthesis was involved in the change of phosphatidylethanolamine methyltransferase level by myo-inositol. 5. These results suggest that the synthesis of phosphatidylcholine from phosphatidylethanolamine by the methylation pathway is regulated...Continue Reading

References

Nov 15, 1976·FEBS Letters·H Fukuyama, S Yamashita
Jan 1, 1978·Zeitschrift für allgemeine Mikrobiologie·M Vidal-Leiria
Feb 21, 1972·Biochimica Et Biophysica Acta·M R Steiner, R L Lester
Feb 15, 1973·Biochimica Et Biophysica Acta·M Vidal-Leiria, N van Uden
Oct 28, 1961·Biochimica Et Biophysica Acta·A SIVAK, O HOFFMANN-OSTENHOF

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Citations

Nov 25, 1997·Biochimica Et Biophysica Acta·S Yamashita, K Hosaka
Oct 20, 2005·Journal of Bioscience and Bioengineering·Miki MiyashitaJun-Ichi Nikawa
Oct 20, 2005·Journal of Bioscience and Bioengineering·Jun-Ichi Nikawa, Junko Kamiuto
Nov 1, 1996·Nucleic Acids Research·J NikawaT Fukuda
Aug 15, 1984·European Journal of Biochemistry·F F BrunnerF Paltauf
Jan 2, 1987·European Journal of Biochemistry·K Hosaka, S Yamashita
Aug 17, 1987·European Journal of Biochemistry·J NikawaS Yamashita
Nov 9, 2006·Bioscience, Biotechnology, and Biochemistry·Jun-ichi NikawaDaisuke Hisada
Jul 26, 2005·Bioscience, Biotechnology, and Biochemistry·Seiichi UchimuraJun-ichi Nikawa
Aug 8, 2008·Bioscience, Biotechnology, and Biochemistry·Yoshitsugu NishikawaJun-ichi Nikawa
Jul 9, 2009·Bioscience, Biotechnology, and Biochemistry·Tomoyuki TakayaJun-ichi Nikawa
Jan 11, 2012·Bioscience, Biotechnology, and Biochemistry·Jun-ichi Nikawa, Minami Kimura
Jan 1, 1984·Critical Reviews in Microbiology·A Chopra, G K Khuller
Jun 7, 1996·The Journal of Biological Chemistry·G M Carman, G M Zeimetz
Aug 11, 1995·The Journal of Biological Chemistry·V M McDonoughG M Carman
Nov 15, 1982·European Journal of Biochemistry·S YamashitaK Hosaka
Jul 1, 1980·Journal of Bacteriology·K Hosaka, S Yamashita
May 1, 1982·Journal of Bacteriology·J NikawaS Yamashita
Jun 25, 1984·Biochimica Et Biophysica Acta·S L Pelech, D E Vance
Jan 1, 1988·Progress in Lipid Research·D E Vance, N D Ridgway
Nov 1, 1984·Molecular and Cellular Biology·B S Loewy, S A Henry
Apr 1, 1990·Journal of Bacteriology·K HosakaS Yamashita

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