PMID: 37055Mar 1, 1978

Regulation of placental enzymes of the carbohydrate and lipid metabolic pathways

Ciba Foundation Symposium
E Shafrir, Y Z Diamant

Abstract

The activity of enzymes with a regulatory function in the pathways of glycolysis, gluconeogenesis, NADPH generation and fatty acid synthesis was measured in the placenta and liver of rats. Compared with the liver, a high activity of pyruvate kinase was found in the placenta, indicating a high glycolytic potential; a small capacity for gluconeogenesis was also present and a moderate to low activity of enzymes associated with lipogenesis. The activity of all placental enzymes fell from day 15 to 20 of gestation irrespective of the pathway they represented. The pattern of decline continued when the gestation was prolonged up to day 26 by the administration of chorionic gonadotropin. The rates of activity disappearance over 11 days of gestation differed for each enzyme, with half-lives ranging from 2.7 days for NADP-malate dehydrogenase to 7 days for glucose-6-phosphate dehydrogenase. In contrast, the activity of hepatic enzymes either remained unchanged or showed individual adaptation to the advancing pregnancy. The regression in placental metabolic capacity after day 15 of gestation was also evident by the decrease in glucose uptake and its channelling to lactate, CO2, glycerol and fatty acids. In addition, placental ageing was a...Continue Reading

Related Concepts

Metabolic Process, Cellular
Biochemical Pathway
Lipogenesis
Glycerin
Malate dehydrogenase (NADP)
Lactate
Measurement of Liver Enzyme
Gluconeogenesis
Enzymes, antithrombotic
Placenta Specimen

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