PMID: 16632759Apr 25, 2006Paper

Regulation of PLAP-1 expression in periodontal ligament cells

Journal of Dental Research
S YamadaS Murakami

Abstract

Periodontal-ligament-associated protein-1 (PLAP-1) is preferentially expressed in the periodontal ligament (PDL) and encodes a novel small leucine-rich repeat proteoglycan protein. PLAP-1 expression was induced during the course of cytodifferentiation of PDL cells into mineralized-tissue-forming cells in vitro, suggesting the possible involvement of PLAP-1 in the mineralization process of PDL cells. In this study, we hypothesized that PLAP-1 expression is regulated by mineralization-related cytokines in PDL cells. PLAP-1 expression was clearly down-regulated when the cytodifferentiation of PDL cells was reversibly inhibited by fibroblast growth factor-2 (FGF-2). In contrast, bone morphogenetic protein-2 (BMP-2) enhanced PLAP-1 expression. Up-regulation of PLAP-1 expression by BMP-2 was confirmed at the protein level when PDL cells were immunostained with anti-PLAP-1 polyclonal antibody. These results revealed the cytokine-mediated regulatory mechanisms of PLAP-1 expression and suggested that PLAP-1 expression may be associated with the process of cytodifferentiation of PDL cells.

References

Jul 1, 1989·The Journal of Cell Biology·D B Rifkin, D Moscatelli
Nov 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L HäkkinenH Larjava
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·R V Iozzo
Dec 31, 1997·Journal of Periodontal Research·S TakayamaH Okada
Nov 16, 2001·Journal of Orthodontics·R J Waddington, G Embery
Jan 26, 2002·Journal of Dental Research·S TakayamaH Okada
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ming ZhaoMartha J Somerman
Apr 18, 2003·Endocrine Reviews·Ernesto CanalisElisabetta Gazzerro
Sep 4, 2003·Development·Renée V Hoch, Philippe Soriano
Dec 2, 2004·Journal of Cellular Physiology·Yoshio ShimabukuroShinya Murakami

❮ Previous
Next ❯

Citations

Apr 30, 2011·Molecular Medicine·Elise DuvalCatherine Baugé
Dec 15, 2015·Archives of Oral Biology·Masae UedaTatsuo Kawamoto
Feb 15, 2007·Journal of Bioscience and Bioengineering·Bruno Braga BenattiFrancisco Humberto Nociti
Apr 15, 2008·Biochemical and Biophysical Research Communications·M TomoedaS Murakami
May 1, 2016·Journal of Dental Research·S YamadaS Murakami
Jan 24, 2014·Journal of Dental Research·T KajikawaS Murakami
Mar 12, 2011·Journal of Periodontal & Implant Science·Hee-Dong ChoiJo-Young Suh
Jul 14, 2016·Oncotarget·Dana SimkovaJan Bouchal
Aug 9, 2017·Scientific Reports·Dong-Joon LeeHan-Sung Jung
May 25, 2007·The Journal of Biological Chemistry·Satoru YamadaShinya Murakami
Oct 15, 2019·Frontiers in Oncology·Shaohua ZhanWei Ge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.