PMID: 688983Apr 1, 1978

Regulation of plasma aldosterone by glucose-induced paradoxical hyperkalemia in the presence of suppressed renin-angiotensin system

J P Rado


In a hyperkalemic patient with stable chronic renal failure and suppression of the renin-angiotensin-aldosterone system intravenous infusion of hypertonic glucose induced a paradoxical transitory rise in serum potassium accompanied by a similar change in plasma aldosterone. The close significant correlation indicated a prominent role for serum potassium in the acute regulation of plasma aldosterone when the renin-angiotensin-aldosterone system was suppressed. However, when the renin-angiotensin-aldosterone system was stimulated by sodium depletion the glucose-induced paradoxical hyperkalemia was abolished and the governing role of potassium became less evident. The results support the concept of an equal and supplementary role of renin-angiotensin-aldosterone system and potassium in the acute regulation of aldosterone production.

Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Angiotensin II, Val(5)-
Blood Chemical Analysis
Glucose, (beta-D)-Isomer

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