Regulation of plasma insulin level by alpha 2-adrenergic receptors

European Journal of Pharmacology
T NakadateR Kato

Abstract

Phentolamine, yohimbine or dihydroergotamine markedly increased plasma immunoreactive insulin (IRI) and inhibited epinephrine-induced hyperglycemia in fasted mice. On the other hand, phenoxybenzamine or prazosin only slightly increased plasma IRI and enhanced epinephrine-induced hyperglycemia. These results indicate that there is a distinct difference in the effects of alpha-adrenergic blockers on the plasma IRI and glucose levels, and that alpha-adrenergic receptors responsible for the plasma IRI level resemble alpha 2-adrenergic receptors more closely.

References

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Citations

Nov 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·J P Hieble, D F Woodward
Aug 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T NakadateR Kato
Jun 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·D J PettiboneJ J Baldwin
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·K IshiiR Kato
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·A Schulz, A Hasselblatt
Oct 15, 1981·European Journal of Pharmacology·T NakadateR Kato
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Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·T NakakiR Kato
Feb 1, 1991·Diabetes Research and Clinical Practice·A Ar'Rajab, B Ahrén
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