Regulation of plasma LDL: the apoB paradigm.

Clinical Science
Allan D SnidermanGerald F Watts

Abstract

The objectives of this analysis are to re-examine the foundational studies of the in vivo metabolism of plasma LDL (low-density lipoprotein) particles in humans and, based on them, to reconstruct our understanding of the governance of the concentration of plasma LDL and the maintenance of cholesterol homoeostasis in the hepatocyte. We believe that regulation of cholesterol homoeostasis within the hepatocyte is demonstrably more complex than envisioned by the LDL receptor paradigm, the conventional model to explain the regulation of plasma LDL and the fluxes of cholesterol into the liver, a model which was generated in the fibroblast but has never been fully validated in the hepatocyte. We suggest that the LDL receptor paradigm should be reconfigured as the apoB (apolipoprotein B) paradigm, which states that the rate at which LDL particles are produced is at least an important determinant of their concentration in plasma as the rate at which they are cleared from plasma and that secretion of cholesterol within VLDL (very-low-density lipoprotein) particles is an important mechanism of maintaining cholesterol homoeostasis within the hepatocyte. These two paradigms are not mutually exclusive. The LDL receptor paradigm, however, inc...Continue Reading

References

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Citations

Dec 27, 2011·Steroids·Robert A Wild
Jun 2, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Max A CayoStephen A Duncan
May 2, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Siti N WulanGuy Plasqui
Apr 21, 2017·Clinical Science·Allan D SnidermanGerald F Watts
Jul 1, 2014·Expert Review of Endocrinology & Metabolism·Mark T Mc Auley, Kathleen M Mooney
Aug 24, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Maurizio AvernaPhilippe Brudi

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Methods Mentioned

BETA
PLASMA

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ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.