Regulation of plasma levels of low-density lipoprotein cholesterol: interpretation of data on low-density lipoprotein turnover in man

Circulation
J B Meddings, J M Dietschy

Abstract

At the present time the most useful technique with which to examine the kinetics of low-density lipoprotein (LDL) cholesterol in vivo is the labeled LDL turnover study. However, a major limitation of this method is that, despite its ability to accurately measure both the plasma LDL concentration and LDL production rate, it cannot directly quantify LDL receptor activity. The present study defines the equations that describe the relationship between LDL cholesterol production rate, LDL receptor number, and plasma LDL cholesterol concentration. These equations provide a method that allows calculation of total LDL receptor activity based on the results of an LDL turnover study. With the use of this technique and data from previously published series, the effects of the genetic absence of receptors, aging, and the treatment of hypercholesterolemia with mevinolin on LDL cholesterol kinetics were analyzed.

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Citations

Oct 26, 1999·The International Journal of Biochemistry & Cell Biology·D Rhainds, L Brissette
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T L InnerarityS M Grundy
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·L A WoollettJ M Dietschy
Feb 1, 1991·The Journal of Clinical Investigation·S EricssonB Angelin
Jul 16, 2014·Reproduction, Fertility, and Development·Tao GuoCong Zhang
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J Havel, R L Hamilton
Nov 20, 2009·Clinical Science·Allan D SnidermanGerald F Watts
May 5, 2006·Fundamental & Clinical Pharmacology·Demiana William FaltaosPhilippe Lechat
Jun 15, 1990·Hospital Practice·J M Dietschy

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