PMID: 9535550Apr 16, 1998Paper

Regulation of podocyte structure during the development of nephrotic syndrome

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
W E Smoyer, Peter Mundel

Abstract

Nephrotic syndrome is a common kidney disease seen in both children and adults. The clinical syndrome includes massive proteinuria, hypoalbuminemia, edema, and usually hypercholesterolemia. Development of these clinical changes is closely correlated with profound structural changes in glomerular epithelial cells, or podocytes, which together with the glomerular basement membrane and endothelium comprise the kidney's blood filtration barrier. Although relatively little is known about the cellular or molecular changes which occur within podocytes during the development of nephrotic syndrome, cytoskeletal proteins very likely play a central role in these changes since they are primarily responsible for the maintenance of cell structure in almost all cells. This review focuses on: (a) the structure and function of podocytes in both the normal state and during nephrotic syndrome and (b) the potential roles of several cytoskeleton-associated proteins identified in podocytes in the development of and/or recovery from the pathophysiological cytoskeletal changes which occur in podocytes during nephrotic syndrome.

Citations

Sep 6, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hsiang-Hao HsuHermann Pavenstädt
Jan 8, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tae-Sun Ha
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A-Ri ChoTakashi Agui
Nov 27, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasheed GbadegesinMichelle Winn
May 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nallasamy Palanisamy, Carani Venkataraman Anuradha
Nov 7, 1999·The American Journal of Pathology·H HolthöferD Kerjaschki
Jan 12, 2002·Kidney International·Arndt T PetermannStuart J Shankland
Jul 9, 2003·Kidney International·Juhani LahdenperäKarl Tryggvason
Jan 21, 2010·The Journal of Biological Chemistry·Jane H KimJohn R Sedor
Jul 4, 2001·The Journal of Experimental Medicine·R DoyonnasK M McNagny
Mar 6, 2004·Hybridoma and Hybridomics·Vesa RuotsalainenKarl Tryggvason
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nigel P GoodeAndrew F Mooney
Oct 18, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Astrid MunkertSigrid Harendza
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·W Kriz, K V Lemley
Dec 13, 2005·Current Opinion in Nephrology and Hypertension·Raghu V Durvasula, Stuart J Shankland
Jan 7, 2005·The FEBS Journal·Xiao Li LiuKarl Tryggvason
Nov 13, 2007·Nephrology·Katsuhiko AsanumaYasuhiko Tomino
Dec 23, 2004·Kidney International. Supplement·Sandra BlancoRamón Romero
Dec 15, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A A MorrisonM R Ladomery
May 27, 2011·American Journal of Physiology. Renal Physiology·Ruma PengalWilliam E Smoyer
Mar 31, 2007·American Journal of Nephrology·Fan YiNingjun Li
Dec 26, 2001·The Journal of Clinical Investigation·K SchwarzP Mundel
Apr 17, 2002·The Journal of Clinical Investigation·Jeffrey H MinerBrendan Lee
Aug 24, 2002·Pediatric Research·Jaakko PatrakkaHannu Jalanko
Aug 11, 2012·PloS One·Li ZouGuo-Ping Zhou
Nov 30, 2007·Journal of the American Society of Nephrology : JASN·Alaa S AwadMark D Okusa
Sep 10, 2011·International Journal of Nephrology·Maddalena GiganteFilippo Aucella
Feb 5, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andreas D KistlerJochen Reiser
Nov 8, 2011·Annual Review of Physiology·Anna Greka, Peter Mundel
Dec 4, 2001·Annals of Medicine·H JalankoC Holmberg
Jan 30, 2016·Journal of the American Society of Nephrology : JASN·Kanae Yamamoto-NonakaYasuhiko Tomino
Nov 20, 2009·Kidney International·Peter Mundel, Jochen Reiser
Jul 14, 2006·Kidney International·C-Y XingP W Mathieson
Jul 14, 2006·Kidney International·J-L R MichaudC R J Kennedy
Jun 28, 2011·European Journal of Pharmacology·Nallasamy PalanisamyCarani Venkataraman Anuradha
May 29, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marcello Camici
Oct 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Byoung Kwon KimHyun Soon Lee
Dec 23, 2011·International Journal of Cell Biology·Beina TengMario Schiffer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.