Regulation of porcine biliary secretion by secretin

Acta Physiologica Scandinavica
S S SaetreO B Schaffalitzky de Muckadell

Abstract

The importance of physiological plasma levels of secretin in biliary bicarbonate secretion is not known. However, in anaesthetized pigs the substantial hepatic output of bicarbonate into the duodenum in response to low doses of secretin exceeds pancreatic bicarbonate output. The aim was therefore to study the relationship between duodenal acidification, secretin and hepatic biliary bicarbonate output in the conscious pig. Göttingen minipigs (n = 22) were cholecystectomized and the common bile duct catheterized. The biliary bicarbonate secretion in response to intraduodenal HCl, secretin or pentagastrin given intravenously, and to meal was studied. Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly. The secretin response to acidification was sufficient to explain the subsequent increase in biliary bicarbonate secretion. Hepatic bicarbonate secretion and concentrations of CCK and secretin in plasma increased postprandially. Exclusion of bile salts from the duodenum abolished postprandial increase in bile volume and increased release of CCK in fasting and fed pigs whereas secretin release was diminished. The results demonst...Continue Reading

References

Aug 1, 1992·Scandinavian Journal of Gastroenterology·R L Riepl, P Lehnert
May 1, 1992·Scandinavian Journal of Gastroenterology·M A AinsworthO B Schaffalitzky de Muckadell
Jan 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R AldiniE Roda
May 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·P Cantor
Apr 1, 1989·Scandinavian Journal of Gastroenterology·I KoopR Arnold
Jan 1, 1987·Reproduction, Nutrition, Development·J AbelloJ P Laplace
May 1, 1985·Digestive Diseases and Sciences·S BondesenO B Schaffalitzky de Muckadell
Jan 1, 1971·Scandinavian Journal of Gastroenterology·S J Konturek
Jan 1, 1981·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellH Worning

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Citations

Mar 3, 2010·Nutrition Research Reviews·Iain A BrownleeJeff P Pearson
Jun 24, 2004·The Tohoku Journal of Experimental Medicine·Michinaga TakahashiSeiki Matsuno

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