Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core.

The Journal of Physiology
Wengang WangNigel S Bamford

Abstract

Interactions between dopamine and glutamate signalling within the nucleus accumbens core are required for behavioural reinforcement and habit formation. Dopamine modulates excitatory glutamatergic signals from the prefrontal cortex, but the precise mechanism has not been identified. We combined optical and electrophysiology recordings in murine slice preparations from CB1 receptor-null mice and green fluorescent protein hemizygotic bacterial artificial chromosome transgenic mice to show how dopamine regulates glutamatergic synapses specific to the striatonigral and striatopallidal basal ganglia pathways. At low cortical frequencies, dopamine D1 receptors promote glutamate release to both D1 and D2 receptor-expressing medium spiny neurons while D2 receptors specifically inhibit excitatory inputs to D2 receptor-expressing cells by decreasing exocytosis from cortical terminals with a low probability of release. At higher cortical stimulation frequencies, this dopaminergic modulation of presynaptic activity is occluded by adenosine and endocannabinoids. Glutamatergic inputs to both D1 and D2 receptor-bearing medium spiny neurons are inhibited by adenosine, released upon activation of NMDA and AMPA receptors and adenylyl cyclase in ...Continue Reading

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Citations

Oct 16, 2012·Nature Neuroscience·Albert QuintanaRichard D Palmiter
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wengang WangNigel S Bamford
Apr 3, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joshua L AllenDeborah A Cory-Slechta
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Dec 12, 2019·Journal of Child Neurology·Jenny L WilsonPennylope Hogarth
Feb 9, 2020·Nature Communications·Laura Domingo-RodriguezRafael Maldonado
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Oct 28, 2019·The Lancet Child & Adolescent Health·Nigel S Bamford, Kathryn McVicar

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