PMID: 6162093Dec 16, 1980Paper

Regulation of presynaptic cellular function. Biochemical studies using clonal neuronal cells

Molecular and Cellular Biochemistry
R McGee

Abstract

Experiments from several different laboratories are reviewed in which clonal neuronal cell lines are being used to study neuronal cellular functions. Primary emphasis is placed on two cell lines, the neuroblastoma X glioma hybrid clone NG108-15 and the pheochromocytoma clone PC12. These particular cell lines are useful because they display many of the properties normally associated with differentiated neurons. The properties which have been studied include: the regulation of adenylate cyclase and the receptors which activate or inhibit its activity, regulation of the cholinergic properties of NG 108-15 and both adrenergic and cholinergic properties of PC12, the response of PC12 to nerve growth factor, and the regulation of synaptogenesis between NG 108-15 cells and cultured muscle. The goal of the review is to not only summarize the information obtained with these two cell lines but also to emphasize the types of research in which clonal cell lines may be most useful in the future.

References

Jan 1, 1978·Annual Review of Neuroscience·P H Patterson
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D G Puro, M Nirenberg
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E J FurshpanD D Potter
May 27, 1977·Science·C N ChristianM Nirenberg
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D SchubertY Kidokoro
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·N M NathansonM Nirenberg
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R McGeeM Nirenberg
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A J BlumeG Boone
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S K SharmaM Nirenberg
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D Schubert, F G Klier
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C N ChristianP G Nelson
Jan 1, 1978·Annual Review of Neuroscience·S S Varon, R P Bunge
Jan 1, 1979·The Journal of Physiology·W B Stallcup
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S K SharmaW A Klee
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S K SharmaM Nirenberg
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P NelsonM Nirenberg
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A LampertW A Klee
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W A Catterall, M Nirenberg
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W A Klee, M Nirenberg
Jan 26, 1973·Biochimica Et Biophysica Acta·T Haga, H Noda
Dec 1, 1973·Journal of Neurochemistry·H I Yamamura, S H Snyder
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W B Stallcup, J Patrick
Oct 1, 1980·Journal of Neurochemistry·R McGee
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P H O'Lague, S L Huttner
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P C MarchisioP Calissano

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