Regulation of Protein Synthesis and Apoptosis in Lymphocytes of Parkinson Patients: The Effect of Dopaminergic Treatment

Neuro-degenerative Diseases
Stéphanie PainJean-Luc Houeto

Abstract

Parkinson disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of the dopaminergic neurons in the substantia nigra, presumably due to increased apoptosis. In previous studies, we showed altered expression of proteins involved in mammalian target of rapamycin (mTOR) antiapoptotic and double-stranded RNA-dependent protein kinase (PKR) apoptotic pathways of translational control in experimental cellular and animal models of PD. In this work, our results showed clear modifications in the expression of kinases involved in mTOR and PKR apoptosis pathways, in lymphocytes of PD patients treated or not with anti-PD treatment (levodopa), which confirmed the role played by apoptosis in the pathogenesis of this disease and the positive effect of treatment with medication on this parameter. Others proteins involved in apo-ptosis were also evaluated in lymphocytes of patients as the expression of the peripheral benzodiazepine receptor and caspase-3. Translational control is altered in PD and hence its evaluation in peripheral blood mononuclear cells may serve as an early marker of apoptosis and indicate the efficacy of the dopaminergic treatment.

References

Mar 1, 1996·Annals of Neurology·J KushleikaP D Swanson
Jan 1, 1997·Journal of Neural Transmission. Supplementum·I ZivE Melamed
Mar 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·E C HirschW C Olanow
Sep 1, 1999·Free Radical Biology & Medicine·E MartignoniG Nappi
Nov 11, 1999·Oncogene·B R Williams
Nov 24, 1999·Biochemical and Biophysical Research Communications·F BonoJ M Herbert
Dec 2, 1999·Experimental Cell Research·A Dufner, G Thomas
May 24, 2000·Progress in Neurobiology·F BlandiniE Martignoni
Nov 1, 2000·Cell·T Schmelzle, M N Hall
Feb 19, 2002·Neurochemistry International·Pierre CasellasAnthony S Basile
Mar 23, 2002·Neurology·Anthony H V Schapira
Nov 5, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F BlandiniG Nappi
Mar 23, 2004·Annals of the New York Academy of Sciences·F BlandiniG Nappi
Sep 7, 2006·Dementia and Geriatric Cognitive Disorders·Marc PaccalinJacques Hugon
Mar 14, 2007·Trends in Pharmacological Sciences·Jean-Martin BeaulieuMarc G Caron
Apr 13, 2010·Toxicology Letters·Julie DeguilStéphanie Pain
Jan 26, 2016·Neuroscience Letters·Nazlı YalçınkayaErdem Tüzün

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Apoptosis

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