Regulation of protein synthesis in human diploid fibroblasts: reduced initiation efficiency in resting cultures
Journal of Cellular Physiology
Feb 1, 1978
Thomas H Meedel, Elliot M Levine
PMID: 621220
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Abstract
The level of poly A+ RNA in growing cultures of human diploid fibroblasts is 1.8-fold times greater than in resting cultures. The level of functional ribosomes in growing cultures is 2.8 times that in resting cultures. Since transit times are similar in both types of cells, it can be co...read more
Mentioned in this Paper
Regulation of Translation
Protein Biosynthesis
Ribosomes
Adenine Polynucleotides
Cycloheximide
Transcription Initiation
Polyribosomes
Specimen Type - Fibroblasts
Interphase Cell
Set of Polysomal Ribosomes
Paper Details
References
- References28
- Citations16
Control of translation in cultured cells: continued synthesis and accumulation of messenger RNA in nondividing cultures
Proceedings of the National Academy of Sciences of the United States of AmericaMarch 1, 1974Philip Spencer Rudland
The metabolism of a poly(A) minus mRNA fraction in HeLa cells
CellSeptember 1, 1974Christine A MilcarekSheldon Penman
Changes in RNA metabolism and accumulation of presumptive messenger RNA during transition from the growing to the quiescent state of cultured mouse fibroblasts
Journal of Molecular BiologyAugust 25, 1975Philip Spencer RudlandAlison R Hunter
Effects of isoleucine deficiency on nucleic acid and protein metabolism in cultured Chinese hamster cells. Continued ribonucleic acid and protein synthesis in the absence of deoxyribonucleic acid synthesis
BiochemistryJanuary 18, 1972M D Enger, Ra'anan TobeyLocalization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells
Journal of Molecular BiologyMay 28, 1968Sheldon PenmanM Penman6Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA
Journal of Molecular BiologyApril 15, 1973W R JelinekJennifer C. DarnellMessenger RNA regulation in humam diploid fibroblasts
Journal of Cellular PhysiologyFebruary 1, 1977Thomas H Meedel, Elliot M LevineIsolation of L-cell messenger RNA which lacks poly(adenylate)
BiochemistryAugust 10, 1976Jay R Greenberg
The effect of high ionic strength on monomers, polyribosomes, and puromycin-treated polyribosomes
Biochimica Et Biophysica ActaMarch 19, 1970E A Zylber, Sheldon PenmanA multiple ribosomal structure in protein synthesis
Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 15, 1963Jonathan R WarnerAdam Rich892
123
- References28
- Citations16
Effects of retinoic acid on protein synthesis in cultured melanoma cells
Journal of Cellular PhysiologyOctober 1, 1982Reuben LotanK Moldave
Utilization of stored messenger RNA during early aging of Jerusalem artichoke tuber slices
PlantaJanuary 1, 1978H Byrne, G Setterfield
Prolonged unbalanced growth induces cellular senescence markers linked with mechano transduction in normal and tumor cells
Biochemical and Biophysical Research CommunicationsSeptember 23, 2005Emi SumikawaDai Ayusawa111Relationship of finite proliferative lifespan, senescence, and quiescence in human cells
Journal of Cellular PhysiologyMarch 1, 1985Gary Stephen SteinC M CorsaroProteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination
Journal of Molecular BiologyFebruary 27, 2009James M BaughEvgeny V Pilipenko1171Ribosomal proteins are synthesized preferentially in cells commencing growth
Journal of Cellular PhysiologyJuly 1, 1982Robert Tushinski, Jonathan R WarnerThe regulation of macrophage protein turnover by a colony stimulating factor (CSF-1)
Journal of Cellular PhysiologyJuly 1, 1983Robert Tushinski, E. Richard Stanley
An avian oncovirus mutant deficient in genomic RNA: characterization of the packaged RNA as cellular messenger RNA
VirologyApril 15, 1979Byron GallisRobert N. EisenmanAbsence of control of poly(A)(+) messenger RNA translation in growth-stimulated mouse 3T6 fibroblasts
Biochimica Et Biophysica ActaJuly 29, 1980Richard E Pratt, Lee F JohnsonRegulation of translation. Analysis of intermediary reactions in protein synthesis in exponentially growing and stationary phase Chinese hamster ovary cells in culture
BiochemistryApril 1, 1980I FischerK Moldave
12
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Regulation of protein synthesis in human diploid fibroblasts: reduced initiation efficiency in resting cultures
Abstract
The level of poly A+ RNA in growing cultures of human diploid fibroblasts is 1.8-fold times greater than in resting cultures. The level of functional ribosomes in growing cultures is 2.8 times that in resting cultures. Since transit times are similar in both types of cells, it can be co...read more
Mentioned in this Paper
Regulation of Translation
Protein Biosynthesis
Ribosomes
Adenine Polynucleotides
Cycloheximide
Related Papers
Paper Details
References
- References28
- Citations16
Control of translation in cultured cells: continued synthesis and accumulation of messenger RNA in nondividing cultures
Proceedings of the National Academy of Sciences of the United States of AmericaMarch 1, 1974Philip Spencer RudlandThe metabolism of a poly(A) minus mRNA fraction in HeLa cells
CellSeptember 1, 1974Christine A MilcarekSheldon PenmanChanges in RNA metabolism and accumulation of presumptive messenger RNA during transition from the growing to the quiescent state of cultured mouse fibroblasts
Journal of Molecular BiologyAugust 25, 1975Philip Spencer RudlandAlison R HunterEffects of isoleucine deficiency on nucleic acid and protein metabolism in cultured Chinese hamster cells. Continued ribonucleic acid and protein synthesis in the absence of deoxyribonucleic acid synthesis
BiochemistryJanuary 18, 1972M D Enger, Ra'anan TobeyLocalization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells
Journal of Molecular BiologyMay 28, 1968Sheldon PenmanM Penman6Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA
Journal of Molecular BiologyApril 15, 1973W R JelinekJennifer C. DarnellMessenger RNA regulation in humam diploid fibroblasts
Journal of Cellular PhysiologyFebruary 1, 1977Thomas H Meedel, Elliot M LevineIsolation of L-cell messenger RNA which lacks poly(adenylate)
BiochemistryAugust 10, 1976Jay R GreenbergThe effect of high ionic strength on monomers, polyribosomes, and puromycin-treated polyribosomes
Biochimica Et Biophysica ActaMarch 19, 1970E A Zylber, Sheldon PenmanA multiple ribosomal structure in protein synthesis
Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 15, 1963Jonathan R WarnerAdam Rich892
123
- References28
- Citations16
Effects of retinoic acid on protein synthesis in cultured melanoma cells
Journal of Cellular PhysiologyOctober 1, 1982Reuben LotanK MoldaveUtilization of stored messenger RNA during early aging of Jerusalem artichoke tuber slices
PlantaJanuary 1, 1978H Byrne, G SetterfieldProlonged unbalanced growth induces cellular senescence markers linked with mechano transduction in normal and tumor cells
Biochemical and Biophysical Research CommunicationsSeptember 23, 2005Emi SumikawaDai Ayusawa111Relationship of finite proliferative lifespan, senescence, and quiescence in human cells
Journal of Cellular PhysiologyMarch 1, 1985Gary Stephen SteinC M CorsaroProteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination
Journal of Molecular BiologyFebruary 27, 2009James M BaughEvgeny V Pilipenko1171Ribosomal proteins are synthesized preferentially in cells commencing growth
Journal of Cellular PhysiologyJuly 1, 1982Robert Tushinski, Jonathan R WarnerThe regulation of macrophage protein turnover by a colony stimulating factor (CSF-1)
Journal of Cellular PhysiologyJuly 1, 1983Robert Tushinski, E. Richard StanleyAn avian oncovirus mutant deficient in genomic RNA: characterization of the packaged RNA as cellular messenger RNA
VirologyApril 15, 1979Byron GallisRobert N. EisenmanAbsence of control of poly(A)(+) messenger RNA translation in growth-stimulated mouse 3T6 fibroblasts
Biochimica Et Biophysica ActaJuly 29, 1980Richard E Pratt, Lee F JohnsonRegulation of translation. Analysis of intermediary reactions in protein synthesis in exponentially growing and stationary phase Chinese hamster ovary cells in culture
BiochemistryApril 1, 1980I FischerK Moldave
12
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