Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kei OhnumaChikao Morimoto

Abstract

Obliterative bronchiolitis is a potentially life-threatening noninfectious pulmonary complication after allogeneic hematopoietic stem cell transplantation and the only pathognomonic manifestation of pulmonary chronic graft-versus-host disease (cGVHD). In the current study, we identified a novel effect of IL-26 on transplant-related obliterative bronchiolitis. Sublethally irradiated NOD/Shi-scidIL2rγ(null) mice transplanted with human umbilical cord blood (HuCB mice) gradually developed clinical signs of graft-versus-host disease (GVHD) such as loss of weight, ruffled fur, and alopecia. Histologically, lung of HuCB mice exhibited obliterative bronchiolitis with increased collagen deposition and predominant infiltration with human IL-26(+)CD26(+)CD4 T cells. Concomitantly, skin manifested fat loss and sclerosis of the reticular dermis in the presence of apoptosis of the basilar keratinocytes, whereas the liver exhibited portal fibrosis and cholestasis. Moreover, although IL-26 is absent from rodents, we showed that IL-26 increased collagen synthesis in fibroblasts and promoted lung fibrosis in a murine GVHD model using IL-26 transgenic mice. In vitro analysis demonstrated a significant increase in IL-26 production by HuCB CD4 T c...Continue Reading

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Citations

Jan 6, 2017·Expert Review of Clinical Immunology·Ida Sofie GrønningsæterHåkon Reikvam
Mar 31, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline PoliPascale Jeannin
Aug 14, 2020·Neurology. Neuroimmunology and Neuroinflammation·Bieke BrouxAlexandre Prat
Jun 13, 2018·Frontiers in Immunology·Esther Caparrós, Rubén Francés
Jul 7, 2020·Acta Histochemica Et Cytochemica·Kiyomi MashimaYoshinobu Kanda
Oct 16, 2018·Frontiers in Immunology·Tue W KragstrupBent Deleuran
Feb 28, 2019·Frontiers in Immunology·Vincent LarochetteYves Delneste
Sep 17, 2020·Science Advances·Michelle H NelsonChrystal M Paulos
Dec 10, 2020·Cytokine & Growth Factor Reviews·Karlhans Fru CheAnders Lindén
Nov 10, 2020·Frontiers in Immunology·Nathaniel Edward Bennett SaiduSara Galimberti
Apr 25, 2021·Life Sciences·Wolfgang JungraithmayrJae-Hwi Jang

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