PMID: 9426695Jan 14, 1998Paper

Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction

International Journal of Cancer. Journal International Du Cancer
Y LiX Zhang

Abstract

Retinoids regulate the growth and differentiation of human tracheobronchial epithelial cells. In this study, we investigated the effects of all-trans-retinoic acid (trans-RA) and receptor class-selective retinoids on the growth and apoptosis of human lung cancer cell lines. Trans-RA significantly inhibited the growth of Calu-6 and H460 cells, accompanied by induction of RA receptor (RAR) beta expression. In contrast, it had little effect on the growth of H292, SK-MES-1 and H661 lung cancer cell lines, in which RAR beta expression was not induced. Stable expression of RAR beta in RAR beta-negative, trans-RA-resistant SK-MES-1 and H661 lung cancer cells led to recovery of trans-RA-induced growth inhibition, which occurred, however, only at low serum concentration. Using fluorescent microscopy and the terminal deoxyribonucleotidyl transferase (TdT) assay, we demonstrated that induction of apoptosis by trans-RA contributed to its growth-inhibitory effect in trans-RA-sensitive lung cancer cell lines. Analysis of RAR-selective and retinoid X receptor (RXR)-selective retionoids showed that activation of both RARs and RXRs could induce growth inhibition in trans-RA-sensitive lung cancer cells. Also, an additive synergistic effect on gr...Continue Reading

References

Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T G HazelL F Lau
Dec 1, 1995·Journal of Cellular Physiology·X S LiA K Rishi
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B HouleW E Bradley
Aug 29, 1996·Nature·J Y ChenH Gronemeyer
Jul 1, 1993·Trends in Endocrinology and Metabolism : TEM·X K Zhang, M Kahl

❮ Previous
Next ❯

Citations

Jun 12, 2012·PPAR Research·Yoko TabeAkimichi Ohsaka
Jun 13, 2000·Cancer Biotherapy & Radiopharmaceuticals·A M BerghellaD Adorno
Jun 19, 2001·BMC Structural Biology·M SchapiraR Abagyan
Jun 11, 2004·Annual Review of Nutrition·Dianne Robert SopranoKenneth J Soprano
Feb 6, 2003·Journal of the National Cancer Institute·Jason S Vourlekis, Eva Szabo
Jun 24, 1999·Journal of the National Cancer Institute·E PicardJ M Vignaud
Jun 24, 1999·Journal of the National Cancer Institute·R Lotan
Mar 25, 2016·PloS One·Agnieszka Anna CzajkaKrystian Jażdżewski
Jul 28, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin Seuk KimDuk-Hwan Kim
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Guo-quan ChenXiao-kun Zhang
May 27, 2003·International Journal of Cancer. Journal International Du Cancer·Belamy CheungGlenn M Marshall
Jul 1, 1999·FEBS Letters·J X MaR K Crouch
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Amanda H ProwseAndrew K Godwin
Jun 8, 2001·Current Oncology Reports·J O Boyle
Apr 26, 2006·The Journal of Biological Chemistry·Belamy B CheungGlenn M Marshall
Feb 6, 2020·Journal of Clinical Medicine·Lara CostantiniNicolò Merendino
Mar 29, 2002·British Journal of Haematology·Helmut R SalihVolkmar Nuessler
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R KhuriX C Xu
Jan 17, 2003·Journal of the National Cancer Institute·Jean-Charles SoriaReuben Lotan
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emile M YoussefReuben Lotan
Jun 30, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Surya Kant TripathiBijesh K Biswal
Jul 25, 2000·Nutrition·R M Niles
Feb 2, 2006·Gene Expression Patterns : GEP·Alexandra TallafussJohn H Postlethwait
Jul 27, 2010·Advanced Drug Delivery Reviews·Nathan Bushue, Yu-Jui Yvonne Wan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.