PMID: 11606798Oct 19, 2001Paper

Regulation of rat carboxylesterase expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): a dose-dependent decrease in mRNA levels but a biphasic change in protein levels and activity

Toxicological Sciences : an Official Journal of the Society of Toxicology
D YangB Yan

Abstract

Carboxylesterases play an important role in the metabolism of endogenous lipids and foreign compounds; therefore, xenobiotic regulation of carboxylesterase gene expression has both physiological and pharmacological significance. We previously reported that beta-naphthoflavone and 3-methylcholanthrene, two potent inducers for cytochrome P4501A enzymes, had opposing effects on the expression of hydrolase S, a secretory carboxylesterase. Beta-naphthoflavone caused suppression, whereas 3-methylcholanthrene caused induction of the expression of this enzyme. The aim of the present study was to determine the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), another prototypical cytochrome P4501A inducer, on the expression of this and several other rat carboxylesterases (hydrolases A, B, and C) in liver and extrahepatic tissues. Rats received TCDD treatment at nonlethal (<or=10 microg/kg), sublethal (30 microg/kg), or lethal doses (90 microg/kg). The overall hydrolytic activity in the liver microsomes toward both 1-naphthyl- and para-nitrophenylacetate was markedly increased in the nonlethal dosage groups, but markedly decreased in the lethal dosage group. Consistent with such a biphasic dose-response relationship, the levels of e...Continue Reading

References

Aug 1, 1975·CRC Critical Reviews in Toxicology·W Junge, K Krisch
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Citations

Sep 6, 2002·Chemico-biological Interactions·Patricia A HarperAllan B Okey
Mar 21, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Youcai ZhangCurtis D Klaassen
Feb 24, 2010·Molecular and Cellular Endocrinology·Georg KretzschmarGünter Vollmer
Aug 22, 2006·Chemico-biological Interactions·Tetsuo Satoh, Masakiyo Hosokawa
Jul 9, 2004·Molecular & Cellular Proteomics : MCP·Qiang TianLeroy E Hood
Jun 3, 2011·Toxicology and Industrial Health·Hai-Ping YinYing Wang

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