Regulation of rat sympathetic nerve density by target tissues and NGF in maturity and old age

The European Journal of Neuroscience
C Thrasivoulou, T Cowen

Abstract

Previous studies in our laboratory using a transplantation model have shown that target tissues of some autonomic neurons, including cerebral blood vessels, exert a controlling influence on nerve fibre loss in old age. The present study was undertaken in order to discover whether the influence of targets extends to controlling age changes in specific populations of nerves. In old rats, we have demonstrated a significant decrease of approximately 50% in the sympathetic innervation of middle cerebral arteries, using tyrosine hydroxylase-like immunoreactivity. Following transplantation, tyrosine hydroxylase-like immunoreactive nerve density on both young and old implanted middle cerebral arteries mirrored the nerve densities seen in normal, non-transplanted vessels. Furthermore, implanted tissue from old donors became reinnervated with a nerve density approximately 50% less than that of young implanted vessels. Treatment of transplants with nerve growth factor, however, was able to reverse these age changes and restore the sympathetic innervation of aged middle cerebral arteries to levels above those seen in young middle cerebral arteries. These results suggest that the pattern and density of sympathetic innervation that the middl...Continue Reading

References

Aug 1, 1990·Trends in Neurosciences·S C Landis
Dec 1, 1991·Hypertension·D Creedon, J B Tuttle
Sep 1, 1991·Neurobiology of Aging·K A Crutcher, J Weingartner
Jan 1, 1990·Brain Research. Molecular Brain Research·W Kedzierski, J C Porter
Jan 1, 1990·Neurobiology of Aging·L G IsaacsonK A Crutcher
Jul 5, 1988·Brain Research·A Claps, F Torrealba
Jul 1, 1989·Trends in Neurosciences·R W Oppenheim
Jan 1, 1985·Stroke; a Journal of Cerebral Circulation·S M Mueller, W L Black
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenR Kettler
Jan 1, 1981·Journal of Neuroscience Research·L YurkewiczE Giacobini
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Korsching, H Thoenen
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L Shelton, L F Reichardt
Nov 14, 1983·Brain Research·R J ThompsonJ Rode
Jun 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H SabaG Burnstock
Jul 1, 1993·Experimental Neurology·I Gavazzi, T Cowen
May 1, 1993·Mechanisms of Ageing and Development·T Cowen
Aug 15, 1993·The Journal of Comparative Neurology·I Gavazzi, T Cowen

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Citations

Jul 11, 2006·Cell and Tissue Research·Caroline SteeleAndrzej Loesch
Nov 11, 2009·Bulletin of Experimental Biology and Medicine·A A BorzykhO S Tarasova
Aug 3, 2007·Journal of Molecular Histology·Andrzej Loesch, Tim Cowen
May 15, 2002·European Journal of Pharmacology·Geert Jan BiesselsWillem Hendrik Gispen
Jan 5, 2002·Neurobiology of Aging·A K Dickason, L G Isaacson
Sep 11, 1998·Neurobiology of Aging·L G Isaacson, K A Crutcher
Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Jan 5, 2002·Autonomic Neuroscience : Basic & Clinical·J C van DenderenR L Bleys
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·B UlfhakB T Fundin
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·Robert E Schmidt
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R L BleysB Hillen
Mar 1, 1996·The European Journal of Neuroscience·H JohnsonB Ulfhake
Nov 1, 2006·Experimental Eye Research·Christopher P SmithJena J Steinle
Dec 8, 2004·The European Journal of Neuroscience·Kliment P GatzinskyTim Cowen
Dec 27, 2005·Neurobiology of Aging·Michael A Bierl, Lori G Isaacson
Jul 15, 1999·The Journal of Comparative Neurology·E BergmanB Ulfhake
May 12, 2017·International Journal of Molecular Sciences·Gaetana MinnoneLuisa Bracci-Laudiero
Apr 22, 2018·Brain Research·Sean M GannonLori G Isaacson
Nov 11, 1996·The Journal of Comparative Neurology·E BergmanB Ulfhake

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