Regulation of renal proximal tubule Na-K-ATPase by prostaglandins.

American Journal of Physiology. Renal Physiology
Maryann B HermanMary Taub

Abstract

Prostaglandins (PGs) play a number of roles in the kidney, including regulation of salt and water reabsorption. In this report, evidence was obtained for stimulatory effects of PGs on Na-K-ATPase in primary cultures of rabbit renal proximal tubule (RPT) cells. The results of our real-time PCR studies indicate that in primary RPTs the effects of PGE(2), the major renal PG, are mediated by four classes of PGE (EP) receptors. The role of these EP receptors in the regulation of Na-K-ATPase was examined at the transcriptional level. Na-K-ATPase consists of a catalytic α-subunit encoded by the ATP1A1 gene, as well as a β-subunit encoded by the ATP1B1 gene. Transient transfection studies conducted with pHβ1-1141 Luc, a human ATP1B1 promoter/luciferase construct, indicate that both PGE(1) and PGE(2) are stimulatory. The evidence for the involvement of both the cAMP and Ca(2+) signaling pathways includes the inhibitory effects of the myristolylated PKA inhibitor PKI, the adenylate cyclase (AC) inhibitor SQ22536, and the PKC inhibitors Gö 6976 and Ro-32-0432 on the PGE(1) stimulation. Other effectors that similarly act through cAMP and PKC were also stimulatory to transcription, including norepinephrine and dopamine. In addition to its e...Continue Reading

References

Jun 1, 1977·The Journal of Clinical Investigation·J B Stokes, J P Kokko
Apr 1, 1991·Circulation Research·H WaldM M Popovtzer
Apr 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·A AperiaP Greengard
Jan 1, 1990·Kidney International·M L SchwartzmanN G Abraham
Jan 1, 1990·The American Journal of Physiology·Y Kinoshita, F G Knox
Aug 1, 1987·The American Journal of Physiology·J NormanL G Fine
Apr 1, 1988·The American Journal of the Medical Sciences·M Mistry, A Nasjletti
Sep 1, 1987·The American Journal of Physiology·J P BonvaletN Farman
Mar 1, 1981·The American Journal of Physiology·F Morel
Jun 1, 1984·The American Journal of Physiology·L M SakhraniL G Fine
Jan 1, 1980·The Journal of Membrane Biology·C A Rabito, D A Ausiello
Sep 1, 1981·The American Journal of Physiology·D W Barfuss, J A Schafer
Dec 1, 1994·The Journal of Clinical Investigation·R C HarrisM D Breyer
Apr 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A AperiaP Greengard
Sep 1, 1993·The Biochemical Journal·S E WilkinsonJ S Nixon
Jan 1, 1993·The American Journal of Physiology·R Cohen-LuriaA Moran
Jan 1, 1997·Methods in Molecular Biology·M Taub
Mar 21, 1998·Pharmacology & Therapeutics·M Raffray, G M Cohen
Sep 15, 1998·Kidney International. Supplement·M D BreyerR M Breyer
Jul 15, 2000·American Journal of Physiology. Renal Physiology·M D Breyer, R M Breyer
Feb 22, 2001·Annual Review of Physiology·M D Breyer, R M Breyer
Jun 16, 2001·American Journal of Physiology. Renal Physiology·R C Harris, M D Breyer

❮ Previous
Next ❯

Citations

Feb 13, 2016·Biochemical and Biophysical Research Communications·Mary Taub
Sep 17, 2015·Traffic·Joseph G LairdSheila A Baker
Jul 12, 2014·BioMed Research International·Marcelo Roberto ChoiBelisario Enrique Fernández
Jan 24, 2012·Biochemical and Biophysical Research Communications·Rania NasrallahRichard L Hébert
Feb 16, 2010·Biochemical and Biophysical Research Communications·Mary TaubFacundo Cutuli
Oct 12, 2013·The American Journal of Pathology·Jean-François ThibodeauChristopher R J Kennedy
Mar 3, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Philipp SchlatterJuergen Drewe
Nov 19, 2015·Frontiers in Cell and Developmental Biology·Zhiqin Li, Sigrid A Langhans
Nov 5, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·François BrazierFrank Bienaimé
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.