Regulation of respiratory and vocal motor pools in the isolated brain of Xenopus laevis

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Erik Zornik, Darcy B Kelley

Abstract

The aquatic frog Xenopus laevis uses a complex vocal repertoire during mating and male-male interactions. Calls are produced without breathing, allowing the frogs to vocalize for long periods underwater. The Xenopus vocal organ, the larynx, is innervated by neurons in cranial motor nucleus (n.) IX-X, which contains both vocal (laryngeal) and respiratory (glottal) motor neurons. The primary descending input to n.IX-X comes from the pretrigeminal nucleus of the dorsal tegmental area of the medulla (DTAM), located in the rostral hindbrain. We wanted to characterize premotor inputs to respiratory and vocal motor neurons and to determine what mechanisms might be involved in regulating two temporally distinct rhythmic behaviors: breathing and calling. Using isolated brain and larynx preparations, we recorded extracellular activity from the laryngeal nerve and muscles and intracellular activity in laryngeal and glottal motor neurons. Spontaneous nerve activities mimicking respiratory and vocal patterns were observed. DTAM projection neurons (DTAM(IX-X) neurons) provide direct input to glottal and laryngeal motor neurons. Electrical stimulation produced short-latency coordinated activity in the laryngeal nerve. DTAM(IX-X) neurons provi...Continue Reading

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Aug 5, 2003·The Journal of Comparative Neurology·Catherine J Brahic, Darcy B Kelley
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May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael SmothermanWalter Metzner
Jan 25, 2007·The Journal of Comparative Neurology·Erik Zornik, Darcy B Kelley
Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heather J RhodesAyako Yamaguchi
May 4, 2007·Proceedings. Biological Sciences·Clémentine Vignal, Darcy Kelley

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Citations

Feb 6, 2009·Nature·Meredith Wadman
Feb 15, 2013·Proceedings. Biological Sciences·Elizabeth C Leininger, Darcy B Kelley
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Mörschel, Mathias Dutschmann
Apr 16, 2010·Journal of Neurophysiology·Erik ZornikAyako Yamaguchi
Dec 15, 2010·Journal of Neurophysiology·Erik Zornik, Ayako Yamaguchi
Oct 6, 2009·The Journal of Experimental Biology·Tine K Rubow, Andrew H Bass
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian C HallDarcy B Kelley
Sep 11, 2010·Current Opinion in Neurobiology·Darcy B Kelley, Andrew H Bass
Jul 16, 2008·Respiratory Physiology & Neurobiology·Mathias DutschmannMiriam Kron
May 13, 2008·Trends in Neurosciences·Erik Zornik, Ayako Yamaguchi
Jul 6, 2014·Current Opinion in Neurobiology·Lora B Sweeney, Darcy B Kelley
Jan 5, 2011·Frontiers in Neuroendocrinology·Erik Zornik, Darcy B Kelley
Jan 18, 2017·Genesis : the Journal of Genetics and Development·Darcy B KelleyErik Zornik
Dec 25, 2016·The Journal of Experimental Biology·Charlotte L BarkanDarcy B Kelley
Oct 11, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Lisa A Mangiamele, Matthew J Fuxjager
Apr 25, 2020·Developmental Neurobiology·Charlotte L Barkan, Erik Zornik
May 5, 2010·Ecological Applications : a Publication of the Ecological Society of America·Fei LuHua Zheng
Aug 20, 2019·The Journal of Experimental Biology·Charlotte L Barkan, Erik Zornik
Mar 9, 2012·The Journal of Experimental Biology·Stéphanie FournierRichard Kinkead
May 27, 2021·Integrative and Comparative Biology·Charlotte L BarkanErik Zornik
Jul 24, 2021·Respiratory Physiology & Neurobiology·Tanya ZubovJoseph M Santin
Apr 1, 2021·Cold Spring Harbor Protocols·Ben G Szaro

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