PMID: 12415742Nov 6, 2002

Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion

Biological Research
William T ArthurKeith Burridge


Integrins and cadherins are transmembrane adhesion receptors that are necessary for cells to interact with the extracellular matrix or adjacent cells, respectively. Integrins and cadherins initiate signaling pathways that modulate the activity of Rho family GTPases. The Rho proteins Cdc42, Rac1, and RhoA regulate the actin cytoskeleton. Cdc42 and Rac1 are primarily involved in the formation of protrusive structures, while RhoA generates myosin-based contractility. Here we examine the differential regulation of RhoA, Cdc42, and Rac1 by integrin and cadherin signaling. Integrin and cadherin signaling leads to a decrease in RhoA activity and activation of Cdc42 and Rac1. When the normal RhoA suppression is antagonized or RhoA signaling is increased, cells exhibited impaired spreading on the matrix protein fibronectin and decreased cell-cell adhesion. Spreading on fibronectin and the formation of cell-cell adhesions is decreased in cells expressing dominant negative forms of Cdc42 or Rac1. These data demonstrate that integrins and cadherins regulate Rho proteins in a comparable manner and lead us to speculate that these changes in Rho protein activity participate in a feedback mechanism that promotes further cell-matrix or cell-cel...Continue Reading


Nov 4, 2005·Histochemistry and Cell Biology·Annette B GallerMatthias Reinhard
Apr 24, 2010·Apoptosis : an International Journal on Programmed Cell Death·Chun-Yung HuangShu-Mei Liang
Apr 10, 2008·Clinical & Experimental Metastasis·Laurie G HudsonM Sharon Stack
Jan 12, 2011·Journal of Materials Science. Materials in Medicine·Yun XiaSubbu S Venkatraman
May 29, 2004·Biochimica Et Biophysica Acta·Claudia PetryAndrea Huwiler
Apr 20, 2010·Nature Cell Biology·Etienne BoulterKeith Burridge
Mar 13, 2008·Médecine sciences : M/S·Arnaud A MailleuxJoan S Brugge
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michio NakayaShigekazu Nagata
Jan 6, 2006·Molecular Biology of the Cell·Disha DadkeErica A Golemis
Aug 26, 2011·Molecular Biology of the Cell·Masao MaedaTakeshi Senga
Jul 4, 2008·American Journal of Physiology. Cell Physiology·Susan J Gunst, Wenwu Zhang
Mar 4, 2005·Arthritis Research & Therapy·Vyacheslav A AdarichevTibor T Glant
Apr 17, 2010·World Journal of Gastroenterology : WJG·Wei-Min HuYong-En Xie
Nov 26, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Debjani GagenDonna M Peters
Dec 19, 2007·The Journal of Cell Biology·Kit WongHenry R Bourne
May 4, 2005·The Journal of Cell Biology·Erik H J DanenArnoud Sonnenberg
Oct 4, 2014·Diabetes·Geraldine ParnaudDomenico Bosco
May 30, 2015·Small GTPases·Cristián A QuinteroMaría T Damiani
Jul 8, 2003·The Journal of Pathology·Erik H J Danen, Arnoud Sonnenberg
Dec 6, 2006·Seminars in Cell & Developmental Biology·P Vasantha Rao, Rupalatha Maddala
Sep 4, 2008·Journal of Cellular Biochemistry·Sirisha AsuriLawrence A Quilliam
Oct 1, 2011·Traffic·Martin N AndersenHanne B Rasmussen
May 10, 2012·Cell Adhesion & Migration·Carolina Epifano, Mirna Perez-Moreno
Feb 11, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Daphna Mokady, David Meiri
Apr 28, 2009·The International Journal of Biochemistry & Cell Biology·Lance DavidsonJian Zhou
Jul 13, 2004·Biochimica Et Biophysica Acta·Alan K Howe
May 1, 2007·Developmental Biology·Guoyan WangFrank Beier
Jun 14, 2005·Developmental Biology·Stéphanie VinotSophie Louvet-Vallée
Dec 19, 2014·Molecular Biology of the Cell·Xinyong TianAnna A Birukova
Dec 4, 2016·International Journal of Cancer. Journal International Du Cancer·Hongyu LiQingyi Wei
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Courtney S SchaffertDean J Tuma
Dec 3, 2003·The Journal of Pathology·Erik H J Danen, Arnoud Sonnenberg
Jan 27, 2004·Oncogene·François BertucciDaniel Birnbaum
Apr 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rupalatha MaddalaVasantha P Rao
Feb 28, 2003·The Journal of Biological Chemistry·Nicole K NorenKeith Burridge
Aug 23, 2018·Molecular Biology of the Cell·Chelsea A Saito-ReisJennifer M Gillette
Jan 27, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander S NovgorodovTatyana I Gudz
Jan 14, 2011·American Journal of Physiology. Cell Physiology·Martin N AndersenHanne B Rasmussen
Jan 17, 2004·The Journal of Biological Chemistry·Guoyan WangFrank Beier
Apr 13, 2004·Journal of Cell Science·Sofia EdlundPontus Aspenström
May 11, 2018·Biological Procedures Online·Yu-Chang ChuangKuang-Wen Liao
May 9, 2013·The Journal of Biological Chemistry·Noureddine ZebdaKonstantin G Birukov
Aug 27, 2017·Journal of Biomedical Science·Hong-Yi ChangHsiao-Sheng Liu
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Twana AlkasaliasTatiana Pavlova
Mar 4, 2008·Molecular Cancer Research : MCR·Annamaria RicciardiLuigi Varesio

Related Concepts

Cell Adhesion
Cell Communication
Microtrabecular Lattice
Signal Transduction
Liver Cell Adhesion Molecule
Rho GTP-Binding Proteins
RhoA GTP-Binding Protein
Cdc42 GTP-Binding Protein
Rac1 GTP-Binding Protein

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.